Hepatitis E virus infection in two different regions of Indonesia with identification of swine HEV genotype 3

Dewiyani Indah Widasari and Yoshihiko Yano and Takako Utsumi and Didik Setyo Heriyanto and Nungki Anggorowati and Hanggoro Tri Rinonce and Totok Utoro and Maria Inge Lusida and Soetjipto and Widya Asmara and Hak Hotta and Yoshitake Hayashi (2013) Hepatitis E virus infection in two different regions of Indonesia with identification of swine HEV genotype 3. Microbiology and Immunology, 57 (10). pp. 692-703. ISSN 03855600

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Official URL: https://onlinelibrary.wiley.com/doi/full/10.1111/1...

Abstract

Hepatitis E is an emerging disease with a high incidence globally. Few data are available on hepatitis E virus (HEV) infection in Indonesia. To obtain molecular information on HEV infection in two regions of Indonesia with different customs and swine breeding conditions, serum samples from 137 swine farm workers, 100 blood donors and 100 swine (27 fecal samples also obtained) in Yogyakarta (Central Java) and from 12 and 64 swine farm workers, 42 and 135 local residents and 89 and 119 swine in Tulungagung (East Java) and Mengwi (Bali), respectively, from our previous study, were compared. Serological tests for anti‐HEV antibodies by ELISA, HEV‐RNA detection by RT‐PCR and phylogenetic analysis were performed. The total prevalence of anti‐HEV antibodies in humans was higher in Bali (11.6%) than in Java (5.1%; P = 0.015). No significant differences in anti‐HEV prevalence among swine farm workers and local residents in Java were found. The finding of swine HEV genotype 3 in specimens from Yogyakarta and genotype 4 from Tulungagung and Bali is somewhat different from other reports. We suggest other factors in addition to close contact with swine might play an important role in HEV transmission of non‐endemic/related custom groups. To the best of our knowledge, this is the first report on swine HEV genotype 3 in Indonesia.

Item Type: Article
Uncontrolled Keywords: hepatitis E virus, Indonesia zoonosis transmission
Subjects: R Medicine > R Medicine (General)
R Medicine > RC Internal medicine
Divisions: 01. Fakultas Kedokteran > Mikrobiologi
Creators:
CreatorsNIM
Dewiyani Indah WidasariUNSPECIFIED
Yoshihiko YanoUNSPECIFIED
Takako UtsumiUNSPECIFIED
Didik Setyo HeriyantoUNSPECIFIED
Nungki AnggorowatiUNSPECIFIED
Hanggoro Tri RinonceUNSPECIFIED
Totok UtoroUNSPECIFIED
Maria Inge LusidaNIDN0017095807
SoetjiptoNIDN0017025004
Widya AsmaraUNSPECIFIED
Hak HottaUNSPECIFIED
Yoshitake HayashiUNSPECIFIED
Depositing User: hanif kurniawan
Date Deposited: 16 Oct 2020 06:24
Last Modified: 16 Oct 2020 06:24
URI: http://repository.unair.ac.id/id/eprint/100202
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