OPTIMASI FASE GERAK METANOL � AIR UNTUK ANALISIS KUANTITATIF CAMPURAN PARASETAMOL DAN KODEIN FOSFAT DENGAN METODE KCKT

Wijayanti, Tri Arini, NIM. 050312704 (2007) OPTIMASI FASE GERAK METANOL � AIR UNTUK ANALISIS KUANTITATIF CAMPURAN PARASETAMOL DAN KODEIN FOSFAT DENGAN METODE KCKT. Skripsi thesis, UNIVERSITAS AIRLANGGA.

[img]
Preview
Text (ABSTRAK)
gdlhub-gdl-s1-2008-wijayantit-9337-ff1540-k.pdf

Download (297kB) | Preview
[img]
Preview
Text (FULLTEXT)
gdlhub-gdl-s1-2009-wijayantit-8932-ff1540-o.pdf

Download (2MB) | Preview
Official URL: http://lib.unair.ac.id

Abstract

Determination of Paracetamol and Codeine Phosphate simultaneously using the reversed phase High-Performance-Liquid-Chromatography (HPLC) have been performed. The mobile phase solution obtained can separate parasetamol from codeine phosphate with good resolution (Rs = 2,704), this mobile phase were a mixture of methanol and phosphate buffer 20 mM pH 2,5 (15:85). The condition of HPLC used were zorbax C8 column, temperature 27°C, flow rate 1,5 ml/minutes and detected by DAD (λ = 284 nm). Linierity of parasetamol and codeine phosphate were good (r paracetamol 0,9999 with Vxo = 0,51 % and r codeine phosphate 0,9999 with Vxo = 1,22 %). Precision instrument for paracetamol and codein phosphate were 0,77 % and 0,79 % respectively. Accuracy of the methods were in the range of accepted limits ( 98 – 102%), average recovery of paracetamol and codeine phosphate in the simulation matrix were 99,99 % and 100,5 % respectively. Precision methods of Parasetamol 0,64% and Codeine phosphat 0,75%. The concentration of paracetamol and codeine phosphate in sample tablet were 100,8% and 99,52% respectively, that are fulfill of USP XXIV requirement ( 90 – 110 % )

Item Type: Thesis (Skripsi)
Additional Information: KKB KK-2 FF. 154/08 Wij o
Uncontrolled Keywords: TABLETING; PARACETAMOL
Subjects: R Medicine > RS Pharmacy and materia medica
R Medicine > RS Pharmacy and materia medica > RS200-201 Pharmaceutical dosage forms
Divisions: 05. Fakultas Farmasi > Kimia Farmasi
Creators:
CreatorsNIM/NIDN
Wijayanti, Tri Arini, NIM. 050312704UNSPECIFIED
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorJuniar Soerjono, Dra., MSUNSPECIFIED
Depositing User: Sulistiorini
Date Deposited: 05 Feb 2009 12:00
Last Modified: 03 Aug 2016 08:24
URI: http://repository.unair.ac.id/id/eprint/10026
Sosial Share:

Actions (login required)

View Item View Item