Noorasmaliza MdPaiman and Siti Aishah Md Ali and Reena MdZin and Meor Zamari Meor Kamal and Wan Anna Md Amin and Mohan Nallusamy and Pavitratha Puspanathan and Rohaizak Muhammad and Sharifa Ezat WanPuteh (2014) Estrogen receptor-negative breast ductal carcinoma: Cllinicopathological features and Mib-1 (Ki-67) proliferative index association. Plos One, 9 (2). ISSN 0089172

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Abstract

Breast cancer estrogen receptor (ER) status is one of the strong additional factors in predicting response of patients towards hormonal treatment. The main aim of this study was to assess the morphological characteristics and proliferative activity using MIB-1(Ki-67) of estrogen receptor negative invasive breast ductal carcinoma (NOS type) as well as to correlate these features with clinicopathological data. We also aim to study the expression of c-erbB2 in ER negative breast tumors. High proliferative rate (MIB-1 above 20%) was observed in 63 (63.6%) of 99 ER negative tumors and that these tumors were associated with high expression of c-erbB2 (57.6%). We observed that MIB-1 is a reliable independent prognostic indicator for ER negative infiltrating ductal carcinoma in this study.

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