Karina Dwi Saraswati and Prihartini Widiyanti and Dwi Gustiono and Jan Setiawan (2017) PLGA-Collagen Composite Synthesis with the Antibacterial Addition of Jatropha curcas L. Leaf Extract as Absorbable Surgical Suture Candidate. Journal of Biomimetics, Biomaterials and Biomedical Engineering, 32. pp. 90-97. ISSN 2296-9845

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Abstract

The prevalence rate of surgical wound infections caused by bacteria is an average of 9% of the 1.4 million patients worldwide. For this reason, a modification of an absorbable surgical suture coated with extract of Jatropha curcas L. leaves to kill and inhibit the growth of microorganisms needs to be made. The forming of multifilament fibers is done by electrospinning method. The test results of the functional groups showed the presence of interaction between PLGA-Collagen with the extract of Jatropha Curcas L. leaves indicated by an absorption band at 2924 cm-1 which showed the vibrations of C-H. The tensile test results showed that all samples were in the range of 19.5-87.1 MPa values which corresponded with the modulus of elasticity of the suture thread in the forehead and elbows. The MTT Assay results showed that the percentage of living cells of all samples was above 50%. The bacterial activity test showed that the inhibition zone were in the range of 5-10 mm. The optimal sample showed the degradation rate of 82.2% on the 60th day of the soaking period. It can be concluded that PLGA-collagen Jatropha curcas L. extracts is safe composite and has potential as antibacterial absorbable surgical sutures.

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