The Role of Hyperbaric Therapy in The Growth of Candida Albicans Repository

The Role of Hyperbaric Therapy in The Growth of Candida Albicans

Prihartini Widiyanti (2013) The Role of Hyperbaric Therapy in The Growth of Candida Albicans. Indonesian Journal of Tropical and Infectious Disease, 4 (4). pp. 23-25. ISSN 2085-1103

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Official URL: https://e-journal.unair.ac.id/IJTID/article/view/2...

Abstract

Background: Candida albicans is opportunistic pathogen fungi which cause many disease in human such as reccurrent apthous stomatitis, skin lesions, vulvavaginitis, candiduria and gastrointestinal candidiasis. Aim: Infection mechanism of C. albicans is very complex including adhesion and invasion, morphology alteration from khamir form cell to filamen form (hifa), biofilm forming and the avoidance of host immunity. Method: The ability of C. albicans to adhere to the host cell which is act as important factor in the early colonization and infection. Result: The phenotype alteration to be filament form let the C. albicans to penetrate to the epithelium and play important role in infection and separation C. Albicans to the host cell. Hyperbaric oxygen is the inhalation of 100 percent oxygen inside hyperbaric chamber that is pressurized to greater than 1 atmosphere (atm). Conclusion: The organism was found to be inhibited within a pressure/time range well tolerated by human subjects, suggesting that hyperbaric oxygen might be used successfully in treating human candidiasis. Latar belakang: Candida albicans merupakan jamur patogen yang berpotensi menyebabkan beberapa penyakit di manusia seperti reccurrent apthous stomatitis, lesi kulit, vulvavaginitis, candiduria dan candidiasis pada gastrointestinal. Tujuan: Mekanisme infeksi C. Albicans sangat kompleks meliputi adhesi dan invasi, perubahan morfologi dari bentukan khamir sel menjadi bentuk filamen (hifa), pembentukan biofilm dan penghindaran terhadap sistem imun tubuh. Metode: Kemampuan C. albicans untuk melekat di sel tubuh yang merupakan faktor penting pada kolonisasi awal dan infeksi. Hasil: Perubahan fenotip menjadi filamen menyebabkan C. albicans berpenetrasi masuk ke epithelium dan berperan dalam infeksi dan pemisahan C. Albicans ke sel tubuh. Hyperbaric oxygen merupakan terapi dengan menggunakan 100 percent oksigen di dalam ruang udara bertekanan tinggi (RUBT)/hyperbaric chamber yang mendapatkan tekanan lebih dari 1 atmosphere (atm). Kesimpulan: Terjadi penghambatan organisme dalam tekanan dan waktu tertentu pada subyek manusia, menunjukkan bahwa hiperbarik oksigen mungkin dapat digunakan dalam terapi human candidiasis.

Item Type:

Article

Uncontrolled Keywords:

Hyperbaric Oxygen, candida albicans, infection, host cell, immunity Oksigen Hiperbarik, candida albicans, infeksi, sel tubuh, imunitas

Subjects:

Q Science > QC Physics > QC1-999 Physics

Divisions:

08. Fakultas Sains dan Teknologi > Tekno Biomedik

Creators: