Dahlia Riyanto (2019) Ekspresi Tgf-Β Dan Fibronektin Setelah Pemberian Propolis Gel Topikal Pada Traumatic Ulcer Tikus Wistar Diabetik. Thesis thesis, UNIVERSITAS AIRLANGGA.
![[img]](https://repository.unair.ac.id/style/images/fileicons/text.png) |
Text
1. HALAMAN DEPAN .pdf Download (319kB) |
|
Text
2. ABSTRAK .pdf Download (82kB) |
|
Text
3. DAFTAR ISI.pdf Download (111kB) |
|
Text
4. BAB I PENDAHULUAN .pdf Download (98kB) |
|
Text
5. BAB II TINJAUAN PUSTAKA .pdf Restricted to Registered users only until 11 December 2023. Download (479kB) | Request a copy |
|
Text
6. BAB III KERANGKA KONSEPTUAL .pdf Restricted to Registered users only until 11 December 2023. Download (114kB) | Request a copy |
|
Text
7. BAB IV METODE PENELITIAN .pdf Restricted to Registered users only until 11 December 2023. Download (175kB) | Request a copy |
|
Text
8. BAB V HASIL PENELITIAN .pdf Restricted to Registered users only until 11 December 2023. Download (517kB) | Request a copy |
|
Text
9. BAB VI PEMBAHASAN .pdf Restricted to Registered users only until 11 December 2023. Download (105kB) | Request a copy |
|
Text
10. BAB VII PENUTUP .pdf Restricted to Registered users only until 11 December 2023. Download (64kB) | Request a copy |
|
Text
11. DAFTAR PUSTAKA.pdf Download (123kB) |
|
Text
12. LAMPIRAN.pdf Restricted to Registered users only until 11 December 2023. Download (293kB) | Request a copy |
|
Text
KESEDIAAN .pdf Restricted to Registered users only Download (53kB) | Request a copy |
Abstract
Background: Diabetes mellitus can cause delayed wound healing includes at in oral cavity because TGF β expression and fibronectin formation decreases. Propolis is one of the herbal medicines using as an alternative therapy of oral ulcer. Objective: to analyze the role of propolis extract gel application from bee husbandry Malang Lawang Regency on the expression of TGF β and fibronectin in the healing process on Wistar rats traumatic oral ulcer with diabetic. Methods: The study was conducted on 27 male Wistar rats divided into three groups. Two groups were induced by 50mg/kg of Streptozotocin, intraperitoneally to provoke hyperglicemia for positive control and treatment groups. One groups without Streptozotocin for negative control. All of the rats were suffered from traumatic ulcer on their lower labial mucosa. The control groups were given with HPMC 5% gel and propolis extract gel was applied on treatment groups. The expression of TGF β and fibronectin was observed on day 3, 5, and 7. Furthermore, rats sacrificed and the lower labial mucosa tissue of rats had been taken for the histopathologycal anatomy preparation in order to examinated of immunohistochemical examination with monoclonal antibodies anti TGF β and monoclonal antibodies anti-fibronectin. Results: This study revealed the expression of TGF β and fibronectin increased in the treatment group rather than positive controls resembling expressions in normal conditions. Conclusion: Propolis extract gel increasing the expression of TGF β and fibronectin during the healing process of traumatic ulcers on the oral mucosa of diabetic Wistar rats.
| Item Type: | Thesis (Thesis) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Additional Information: | KKA KK PPDGS IPM 05/20 Riy E | |||||||||
| Uncontrolled Keywords: | diabetes mellitus, ulcer healing process, TGF β expression, fibronectin expression | |||||||||
| Subjects: | R Medicine > RA Public aspects of medicine > RA1-1270 Public aspects of medicine > RA421-790.95 Public health. Hygiene. Preventive medicine > RA773-788 Personal health and hygiene | |||||||||
| Divisions: | 02. Fakultas Kedokteran Gigi > Oral Medicine | |||||||||
| Creators: |
|
|||||||||
| Contributors: |
|
|||||||||
| Depositing User: | mrs siti muzaroh | |||||||||
| Date Deposited: | 15 Dec 2020 04:53 | |||||||||
| Last Modified: | 15 Dec 2020 04:53 | |||||||||
| URI: | http://repository.unair.ac.id/id/eprint/101463 | |||||||||
| Sosial Share: | ||||||||||
Actions (login required)
 |
View Item |