Effect of vitamin C on xenobiotic metabolism and histopathology of fetal brain of lead exposed mice Repository

Effect of vitamin C on xenobiotic metabolism and histopathology of fetal brain of lead exposed mice

Agoes Soegianto and J. Christyaningsih and H. Notopuro and W. Darmanto (2014) Effect of vitamin C on xenobiotic metabolism and histopathology of fetal brain of lead exposed mice. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 5 (4). pp. 855-864.

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

The objectives of this study are to investigate the effect of vitamin C on xenobiotic metabolism and histopathology of fetalbrain of mice after exposed to lead. The experiment used 27 pregnant mice and divided into three groups: the negative control group (NC), which wastreated with distilled water, the positive control group (PC) was exposed to 25 mg Pb/kg body weight (BW)/day, and the third group (T) was exposed to 25 mg Pb/kg BW/day during gestation day 7 to 16 and then administered with 64 mg vitamin C/kg BW/day started on the gestation day 9 to 16. Both lead and vitamin C were given to mice orally. The result showed that supplementationof vitaminCprovided protectionto thefetus. The histological structure of fetal brain administered to vitamin C (T) was betterthan PC. Theaverage concentration of lead inits fetal head (T) is the lowestamongthe othergroups. Supplementation of vitamin C can protect liver and fetuses, suggesting that vitamin C could bind the lead and excrete it via urine.

Item Type:

Article

Additional Information:

cited By 1

Uncontrolled Keywords:

ascorbic acid; cytochrome P450 1A1; glutathione transferase; lead; water; xenobiotic agent, animal experiment; animal tissue; article; brain cortex; brain level; brain tissue; controlled study; corpus callosum; cortical thickness (brain); enzyme activity; female; fetus; gestation period; histopathology; lead poisoning; liver homogenate; liver microsome; liver protection; metal binding; mouse; neuroprotection; nonhuman; perinatal drug exposure; pregnancy; urinary excretion; vitamin supplementation; xenobiotic metabolism

Divisions:

Artikel Ilmiah > SCOPUS INDEXED JOURNAL

Creators:

Creators	NIM
Agoes Soegianto	UNSPECIFIED
J. Christyaningsih	UNSPECIFIED
H. Notopuro	UNSPECIFIED
W. Darmanto	UNSPECIFIED

Depositing User:

Ika Rudianto

Last Modified:

30 Dec 2020 01:48

URI:

http://repository.unair.ac.id/id/eprint/102239

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