KARAKTERISASI KOMPLEKS INKLUSI KETOPROFEN – HIDROKSIPROPIL-Β-SIKLODEKSTRIN (DIBUAT DENGAN METODE KNEADING)

Windia Rakhmandasari Putri (2015) KARAKTERISASI KOMPLEKS INKLUSI KETOPROFEN – HIDROKSIPROPIL-Β-SIKLODEKSTRIN (DIBUAT DENGAN METODE KNEADING). Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Official URL: http://lib.unair.ac.id

Abstract

The aim of this study was to formed the inclusion complex between ketoprofen and hydroxyprophyl-β-cyclodextrin and thus enhance dissolution profile and bioavailability of the ketoprofen. Solubility studies demonstrated the formation of the ketoprofren – hydroxyprophyl-β-cyclodextrin inclusion complex with 1:1 stoichiometry. The solid state of inclusion complex were prepared and characterized by X-ray Diffraction, Differential Thermal Analysis (DTA), and Infrared Spectrophotometry. X-ray studies demonstrated that there was significant drecrease of ketoprofen’s intensity in inclusion complex compared with pure ketoprofen, but physical mixture showed the superposition between ketoprofen and hydroxyprophyl-β-cyclodextrin’s diffractogram. DTA studies showed the multiple peak of inclusion complex because of grinding that used for formation of inclusion complex. The characterization using spectrophotometer IR showed that inclusion complex’s spectra was identical with hydroxyprophyl-β-cyclodextrin spectra because formation of hydrogen bonding of ketoprofen with hydroxyprophyl-β-cyclodextrin. All methods showed that the inclusion complex has been formed with amorphous structure.

Item Type: Thesis (Skripsi)
Additional Information: KKB KK-2 FF F.11/14 Put k
Uncontrolled Keywords: Inclusion Complex, Ketoprofen, Hydroxyprophyl-Β-Cyclodextrin, Kneading, Characterization
Subjects: R Medicine
R Medicine > RS Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi
Creators:
CreatorsNIM/NIDN
Windia Rakhmandasari PutriNIM051011086
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorBambang Widjaja, -UNSPECIFIED
ContributorACHMAD RADJARAM, -UNSPECIFIED
Depositing User: Nn Deby Felnia
Date Deposited: 02 Feb 2015 12:00
Last Modified: 23 Jan 2020 11:44
URI: http://repository.unair.ac.id/id/eprint/10249
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