Taufiq Gemawan (2020) Hubungan Kadar Il-6 Dan Profil Lipid Sebagai Prediktor Ventilator Associated Pneumonia (Vap) Di Rsud Dr. Soetomo Surabaya. Thesis thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Background : Respiration support by mechanical ventilation is an important aspect in intensive care. However, it could induce complication as infection. Ventilator Associated Pneumonia (VAP) is the most common infection in patient with ventilator support. This infection have an impact to patient’s length of stay and prognosis. VAP will be followed with inflamatory responses consist of elevation IL-6 level and lipid profile abnormality. Therefore objective evaluation for acute inflamation could be a tool to diagnose VAP early. Method : This study is analitic observational with prospektif design, to know the relationship of IL-6 dan lipid profile (HDL and LDL) toward VAP incidence in 38 patient under Intensive Care treatment. Subject observed for 7 days and IL-6, HDL,LDL levels were examined in the day with ventilator and 48 hours after it. Result : VAP occur in 23 subject (65,53%) from all population. IL-6 (1), IL-6(2) and ∆ IL-6 levels have significant effect to VAP incidence. HDL (1), HDL (2), LDL (1), and LDL (2) levels have significant effect to VAP group. And ∆ HDL and ∆ LDL levels have significant effect to both group, VAP and non-VAP subjects. Conclusion : IL-6, HDL and LDL level change have relation as predictor VAP incidence.

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