Mehran Fadaeinasab, - and Hairin Taha, - and Putri Narrima Mohd Fauzi, - and Hapipah Mohd Ali, - and Aty Widyawaruyanti, - (2015) Anti-malarial Activity of Isoquinoline Alkaloids from the Stem Bark of Actinodaphne macrophylla. Natural Product Communications, 10 (9). pp. 1541-1542. ISSN 1934-578X
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Abstract
Seven isoquinoline alkaloids isolated from the bark of Actinodaphne macrophylla in this study demonstrated in vitro antiplasmodial activities against Plasmodium falciparum 3D7 with IC50 values of 0.08 μM, 0.05 μM, 1.18 μM, 3.11 μM, 0.65 μM, 0.26 μM, and 1.38 μM for cycleanine, 10-demethylxylopinine, reticuline, laurotetanine, bicuculine, α-hydrastine and anolobine, respectively, which are comparable with the reference standard, chloroquine. 10-Demethylxylopinine was found to be the most active of these compounds.
| Item Type: | Article | ||||||||||||
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| Uncontrolled Keywords: | Actinodaphne macrophylla, Lauraceae, Isoquinoline alkaloids, Antiplasmodial activity, Plasmodium falciparum 3D7 | ||||||||||||
| Subjects: | R Medicine R Medicine > RS Pharmacy and materia medica R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica R Medicine > RS Pharmacy and materia medica > RS200-201 Pharmaceutical dosage forms |
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| Divisions: | 05. Fakultas Farmasi | ||||||||||||
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| Depositing User: | Mr M. Fuad Sofyan | ||||||||||||
| Date Deposited: | 15 Jul 2021 01:49 | ||||||||||||
| Last Modified: | 05 Oct 2021 05:09 | ||||||||||||
| URI: | http://repository.unair.ac.id/id/eprint/102679 | ||||||||||||
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