Che Puteh Osman, - and Nor Hadiani Ismail, - and Rohaya Ahmad, - and Aty Widyawaruyanti, - and Lidya Tumewu, - and Chee Yan Choo, - and Sharinah Ideris, - (2017) Evaluation of Rennellia Elliptica as Potential Antiplasmodial Herbal Remedy. Jurnal Teknologi (Sciences & Engineering), 79 (6). pp. 37-43. ISSN 2180-3722

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Abstract

Rennellia elliptica (Rubiaceae) has been used by local Jakun Community in the Endau Rompin State Park for the treatment of jaundice. Previous study has revealed the antiplasmodial activity of the root extract and major anthraquinones isolated from the roots. The present study entails the optimization of extraction methods, qualitative and quantitative analyses of selected marker anthraquinones and in vivo antiplasmodial activity along with toxicity and inhibition of β-hematin in vitro. HPLC profile showed the present of marker compounds as major constituents with content ranging 3-12 µg/g extract. The root extract showed potent antiplasmodial activity against rodent malaria, Plasmodium berghei with ED50 value of 1.23 µg/ml BW. The major anthraquinones, damnacanthal and nordamnacanthal showed significant inhibition against β-hematin formation via lipids and HRP2 catalyses. However, the root extract is slightly toxic against hepatocyte cell. These data suggests that R. elliptica is a potential herbal remedy for malaria treatment and antiplasmodial of the root extract possibly due to the action of major anthraquinones.

Item Type:	Article
Uncontrolled Keywords:	Rennellia elliptica, antiplasmodial, anthraquinones, Plasmodium, malaria
Subjects:	R Medicine R Medicine > RS Pharmacy and materia medica R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica R Medicine > RS Pharmacy and materia medica > RS200-201 Pharmaceutical dosage forms
Divisions:	05. Fakultas Farmasi
Creators:	Creators NIM Che Puteh Osman, - - Nor Hadiani Ismail, - - Rohaya Ahmad, - - Aty Widyawaruyanti, - NIDN0026046210 Lidya Tumewu, - - Chee Yan Choo, - - Sharinah Ideris, - -
Depositing User:	Mr M. Fuad Sofyan
Date Deposited:	15 Jul 2021 01:46
Last Modified:	06 Oct 2021 06:19
URI:	http://repository.unair.ac.id/id/eprint/102681
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