PERBANDINGAN DAYA ADSORPSI NORIT DAN ATTAPULGIT TERHADAP SIPROFLOKSASIN HCL DAN OFLOKSASIN

WINNI RAHMAWATI, 051111177 (2016) PERBANDINGAN DAYA ADSORPSI NORIT DAN ATTAPULGIT TERHADAP SIPROFLOKSASIN HCL DAN OFLOKSASIN. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Diarrhea is a disease that commonly occurs in Indonesia. One of diarrhea type is the specific one which is caused by bacterial infection. For the treatment, adsorbents - antibiotic combinations are usually given. Adsorbents, e. g. activated carbon and attapulgite, are used to adsorb toxins and antibiotics are given to overcome the bacterial growth. Adsorbents nonspecifically adsorb not only toxins but also nutritions, water or even drugs so antibiotics are also possibly adsorbed and it can affect the treatment effectivity. The purpose of this study is to know the adsorption capacity of activated carbon and attapulgite against ciprofloxacin HCl and ofloxacin, then compare it. Determination of antibiotics level is performed by UV-Vis spectrophotometry with maximum wavelength 273 for ciprofloxacin HCl and 287 for ofloxacin. Results can be concluded by obtain adsorption percentage and k values of each antibiotic - adsorbent. Activated carbon - ciprofloxacin HCl’s k = 19,543; % = 22,58; attapulgite - ciprofloxacin HCl’s k = 0,096; % = 14,40; activated carbon - ofloxacin’s k = 51,286; % = 23,80; attapulgite – ofloxacin’s k = 7,328; % = 15,64. The result shows that adsorption capacity of activated carbon - ofloxacin is greater than activated carbon - ciprofloxacin HCl, meanwhile attapulgite - ofloxacin is greater than attapulgite - ciprofloxacin HCl. Adsorption capacity of activated carbon - ofloxacin is greater than the of attapulgite - ofloxacin, meanwhile activated carbon - ciprofloxacin HCl is greater than the attapulgite - ciprofloxacin HCl. It can be concluded that at various concentrations, activated carbon and attapulgite can adsorb ciprofloxacin HCl and ofloxacin so these two have to be given with the time interval separately.

Item Type: Thesis (Skripsi)
Additional Information: KKB KK-2 FF.KF.32/15 Rah p
Uncontrolled Keywords: ADSORPTION; CIPROFLOXACIN HYDROCHLORIDE
Subjects: R Medicine
R Medicine > RS Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi
Creators:
CreatorsEmail
WINNI RAHMAWATI, 051111177UNSPECIFIED
Contributors:
ContributionNameEmail
ContributorPURWANTO, Prof. Dr. Apt.UNSPECIFIED
ContributorSUKO HARDJONO, Dr. Apt., M.S.UNSPECIFIED
Depositing User: Nn Deby Felnia
Date Deposited: 23 Feb 2016 12:00
Last Modified: 24 Oct 2016 18:36
URI: http://repository.unair.ac.id/id/eprint/10283
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