PERBANDINGAN SINTESIS p-METOKSISINAMOILHIDRAZIDA MENGGUNAKAN METODE PEMANASAN KONVENSIONAL DAN IRADIASI GELOMBANG MIKRO

RATNA NUSANDARI, 051111092 (2016) PERBANDINGAN SINTESIS p-METOKSISINAMOILHIDRAZIDA MENGGUNAKAN METODE PEMANASAN KONVENSIONAL DAN IRADIASI GELOMBANG MIKRO. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

In the previous studies showed that ethyl p-methoxycinnamate (EPMC) have a lot of bioactivities, such as analgesic and anti inflamation by inhibiting COX. It is promising to be modified as a COX-2 selective inhibitor, due to its characteristic structure. In this study, EPMC as the starting material was isolated from Kaempferia galanga L. and being reacted with hydrazine hydrate to obtain p-methoxycinnamoylhydrazide. This synthesis was carried out using conventional thermal heating and microwave irradiation. Microwave irradiation was one of the methods that could reducing reaction time and increasing yield. The product was purified by column chromatography to give a purified product, which was analyzed using TLC test, melting point test, IR, 1H-NMR, and UV spectroscopies to determine its structure. It was concluded that p-methoxycinnamoylhydrazide was not obtained. So, the yields from two methods could not be compared.

Item Type: Thesis (Skripsi)
Additional Information: KKB KK-2 FF.KF.35/15 Nus p
Uncontrolled Keywords: P-METHOXYCYNNAMOYLHYDRAZIDE
Subjects: R Medicine
R Medicine > R Medicine (General) > R5-130.5 General works
R Medicine > RS Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi
Creators:
CreatorsEmail
RATNA NUSANDARI, 051111092UNSPECIFIED
Contributors:
ContributionNameEmail
ContributorMELANNY IKA, S.Farm., M.Sc., AptUNSPECIFIED
ContributorMARCELLINO, Drs. Apt., M.Si., Ph.DUNSPECIFIED
Depositing User: Nn Deby Felnia
Date Deposited: 24 Feb 2016 12:00
Last Modified: 24 Oct 2016 19:15
URI: http://repository.unair.ac.id/id/eprint/10286
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