PENGARUH SUBSTITUEN 2-METOKSI PADA SINTESIS TURUNAN 2-HIDROKSIBENZOHIDRAZIDA DENGAN IRADIASI GELOMBANG MIKRO GEMILANG HARDYANPUTRINDA

GEMILANG HARDYANPUTRINDA, 051111031 (2016) PENGARUH SUBSTITUEN 2-METOKSI PADA SINTESIS TURUNAN 2-HIDROKSIBENZOHIDRAZIDA DENGAN IRADIASI GELOMBANG MIKRO GEMILANG HARDYANPUTRINDA. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

N’-benzylidene-2-hydroxybenzohydrazide and N’-(2- methoxybenzylidene)-2-hydroxybenzohydrazide are hydrazide derived compounds that could be made from methyl salicylate. The aim of this research is to determine the influence of 2- methoxy substituent in the synthesis of N’-(2-methoxybenzylidene)- 2-hydroxybenzohydrazide through the yields of synthesis comparisons with N’-benzylidene-2-hydroxybenzohydrazide by microwave irradiation. N’-(2-methoxybenzylidene)-2-hydroxybenzohydrazide synthesized from structure modification of methyl salicylate through 2 phases of reaction, nucleophilic acyl substitution to produce 2-hydroxybenzohydrazide and nucleophilic addition to produce target compound. Methoxy group influences carbonyl reactivity through resonance and steric effect in nucleophilic addition. N’-benzylidene-2-hydroxybenzohydrazide is white, needleshaped crystal (88 ± 2.5)% and N’-(2-methoxybenzylidene)-2- hydroxybenzo-hydrazide is white round solids (76 ± 3.5)%. Concluded that 2-methoxy substitutient decrease carbonyl reactivity in nucleophilic addition of N’-(2-methoxybenzylidene)-2-hydroxybenzohydrazide synthesis.

Item Type: Thesis (Skripsi)
Additional Information: KKB KK-2 FF.KF.61/15 Har p
Uncontrolled Keywords: 2-METHOXY SUBSTITUENT
Subjects: R Medicine
R Medicine > RS Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi
Creators:
CreatorsEmail
GEMILANG HARDYANPUTRINDA, 051111031UNSPECIFIED
Contributors:
ContributionNameEmail
ContributorJUNI EKOWATI, Dr. Apt., MSi.UNSPECIFIED
ContributorMARCELLINO, Drs. Apt., MSi., PhDUNSPECIFIED
Depositing User: Nn Deby Felnia
Date Deposited: 08 Mar 2016 12:00
Last Modified: 25 Oct 2016 16:35
URI: http://repository.unair.ac.id/id/eprint/10301
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