SINTESIS N�-BENZILIDENISONIAZIDA DAN N�-(4-HIDROKSI-3-METOKSI BENZILIDEN) ISONIAZIDA DENGAN METODE IRADIASI GELOMBANG MIKRO

TITA ALVINDA KOSASIH, 051111107 (2016) SINTESIS N�-BENZILIDENISONIAZIDA DAN N�-(4-HIDROKSI-3-METOKSI BENZILIDEN) ISONIAZIDA DENGAN METODE IRADIASI GELOMBANG MIKRO. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

The aim of this study was to synthesize N’-(4-hydroxy-3- methoxybenzylidene)isoniazide using microwave irradiation method. The target compound was synthesized by reacting vanilline with isoniazide (2:1). Purity test was done by thin layer chromatography (TLC) and melting point. As a comparison, N’-benzylideneisoniazide was synthesized by reacting benzaldehyde with isoniazide (2:1) to prove that vanilline (4-hydroxy-3-methoxybenzaldehyde) is more reactive than benzaldehyde in reaction with isoniazide. Identifications of synthesized compound (product) were confirmed by UV-VIS, FT-IR and 1H-NMR spectroscopy. Percentage yield of N’-(4-hydroxy-3- methoxybenzylidene)isoniazide and N’-benzylideneisoniazide were 82 % and 77 %, respectively.

Item Type: Thesis (Skripsi)
Additional Information: KKB KK-2 FF.KF.64/15 Kos s
Uncontrolled Keywords: ISONIAZIDE
Subjects: R Medicine
R Medicine > R Medicine (General) > R5-130.5 General works
R Medicine > RS Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi
Creators:
CreatorsEmail
TITA ALVINDA KOSASIH, 051111107UNSPECIFIED
Contributors:
ContributionNameEmail
ContributorHADI POERWANTO, Drs. Apt., MSc., PhDUNSPECIFIED
ContributorACHMAD SJAHRANI, Prof. Dr. Apt., MS.UNSPECIFIED
Depositing User: Nn Deby Felnia
Date Deposited: 08 Mar 2016 12:00
Last Modified: 25 Oct 2016 16:40
URI: http://repository.unair.ac.id/id/eprint/10303
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