LC ESI-MS and FT-IR Analysis of Dendrophthoe pentandra L. Miq Leaf Methanolic Extracts to Identify Compounds with Progesterone-Like Effects

Mochammad Lazuardi and Bambang Hermanto (2016) LC ESI-MS and FT-IR Analysis of Dendrophthoe pentandra L. Miq Leaf Methanolic Extracts to Identify Compounds with Progesterone-Like Effects. Pakistan Journal of Nutrition, 15 (3). pp. 274-282. ISSN 1680-5194

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Official URL: https://scialert.net/abstract/?doi=pjn.2016.274.28...

Abstract

An earlier study found that progesterone hormone levels in adult female rats increased by nearly two-fold relative to usual levels following intramuscular injection (w/v, 100 mg/kg body weight for four days (s.d.d.)) of methanol extracts of Dendrophthoe petandra L. Miq (common name Benalu duku) leaves. This result suggests that Benalu duku contains pregnane derivative steroids that have carbon bonding at positions 1 and 21. Here we examined the specificity and pharmacodynamics of active substances with progesterone-like effects in crude methanol extracts made from Benalu duku leaves. Pulverized Benalu duku leaves (400 g) were extracted with 2 L analytical grade methanol at 20°C for 72 h using a shaker maceration method. The semi-solid crude extract was dried under vacuum and exposed to UV light prior to spectroscopic analysis. FT-IR and LC ESI MS analysis detected active substances having a pregnane derivative chemical structure with progesterone, medroxy progesterone acetate, megestrol acetate and dydrogesterone present at distributions of about 30, 66, 3 and 1% Key words : benalu duku, pregnane derivate, anabolic steroid, leaf extract FT-IR Methanolic leaf extract LC- ESI MS

Item Type: Article
Uncontrolled Keywords: Benalu duku, pregnane derivate, anabolic steroid, leaf extract FT-IR Methanolic leaf extract LC- ESI MS
Subjects: S Agriculture > SF Animal culture > SF405.5-407 Laboratory animals
S Agriculture > SF Animal culture > SF600-1100 Veterinary medicine > SF910 Other diseases and conditions
Creators:
CreatorsNIM
Mochammad LazuardiNIDN0018125804
Bambang HermantoUNSPECIFIED
Depositing User: Nn Erna Dwi Indriyani
Date Deposited: 18 Feb 2021 13:45
Last Modified: 18 Feb 2021 13:45
URI: http://repository.unair.ac.id/id/eprint/104032
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