Penggunaan Brimonidin (Agois Alfa-2 Adrenergik) sebagai Terapi Glaukoma

Heni Riyanto and Nurwasis and Rahardjo (2007) Penggunaan Brimonidin (Agois Alfa-2 Adrenergik) sebagai Terapi Glaukoma. Jurnal Oftalmologi Indonesia, 5 (1). pp. 27-39. ISSN 16932587

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Abstract

Brimonidine is a highly selective alpha2-adrenoceptor agonist which reduces intraocular pressure (IOP) by reducing aqueous humor production and increasing aqueous humor outflow via the uveoscleral pathway. Brimonidine is indicated for the topical management of open-angle glaucoma or ocular hypertension. The reommended dose of brimonidine 0,2% is one drop in the affected eye two or three times daily, approximately three hours apart. A dose-response effect was observed after single dose administration of brimonidine to pattients with glaucoma or ocular hypertension; IOP reductions from baseline of 16,1, 22,4 and 30,1% were achieved after administration of brimonidine 0,08, 0,2 or 005%, respectively. The most frequent adverse events associated with brimonidine therapy were oral dryness (30,0%), ocular hyperaemia (26,3%) and ocular burning and/or stinging (24,0%). Brimonidine may have the potential additional benefit of providing neuroprotection for glaucoma patients. Studies have already demonstrated that brimonidine meets 3 of the 4 criterian used in evaluating neuroprotective agents, and clinical trials are in progress to determine whether brimonidine also fulfills the last criterian and is there neuroprotective effect in human eyes.

Item Type: Article
Uncontrolled Keywords: brimonidine, alpha 2 adrenoceptor agonist, IOP reduction, neuroprotection
Subjects: R Medicine > R Medicine (General)
R Medicine > RE Ophthalmology
Divisions: 01. Fakultas Kedokteran > Ilmu Penyakit Mata
Creators:
CreatorsNIM
Heni RiyantoUNSPECIFIED
NurwasisNIDN8859130017
RahardjoUNSPECIFIED
Depositing User: hanif kurniawan
Date Deposited: 23 Feb 2021 13:30
Last Modified: 23 Feb 2021 13:30
URI: http://repository.unair.ac.id/id/eprint/104174
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