Farah Mahdiyyah (2020) Pengaruh Penggunaan Protektan Pada Proses Freeze Drying Terhadap Karakteristik Misel : Literature Review. Skripsi thesis, UNIVERSITAS AIRLANGGA.
![[img]](https://repository.unair.ac.id/style/images/fileicons/text.png) |
Text (HALAMAN JUDUL)
1. HALAMAN JUDUL.pdf Download (1MB) |
|
Text (ABSTRACT)
2. ABSTRACT.pdf Download (886kB) |
|
Text (BAB I PENDAHULUAN)
3. BAB I PENDAHULUAN.pdf Download (917kB) |
|
Text (DAFTAR ISI)
3. DAFTAR ISI.pdf Download (995kB) |
|
Text (BAB II TINJAUAN PUSTAKA)
4. BAB II TINJAUAN PUSTAKA.pdf Restricted to Registered users only until 19 February 2024. Download (1MB) | Request a copy |
|
Text (BAB III KERANGKA KONSEPTUAL)
5. BAB III KERANGKA KONSEPTUAL.pdf Restricted to Registered users only until 19 February 2024. Download (907kB) | Request a copy |
|
Text (BAB IV METODE PENELITIAN)
6. BAB IV METODE PENELITIAN.pdf Restricted to Registered users only until 19 February 2024. Download (771kB) | Request a copy |
|
Text (BAB V HASIL DAN PEMBAHASAN)
7. BAB V HASIL DAN PEMBAHASAN.pdf Restricted to Registered users only until 19 February 2024. Download (1MB) | Request a copy |
|
Text (BAB VI KESIMPULAN DAN SARAN)
8. BAB VI KESIMPULAN DAN SARAN.pdf Restricted to Registered users only until 19 February 2024. Download (766kB) | Request a copy |
|
Text (DAFTAR PUSTAKA)
9. DAFTAR PUSTAKA.pdf Download (934kB) |
|
Text (LAMPIRAN)
10. LAMPIRAN.pdf Restricted to Registered users only until 19 February 2024. Download (1MB) | Request a copy |
|
Text (PERMOHONAN EMBARGO)
PERMOHONAN EMBARGO.pdf Restricted to Registered users only until 19 February 2024. Download (172kB) | Request a copy |
Abstract
Micelles are one of drug carrier that can increase the solubility of hydrophobic drugs. By nature, micelles are not stable both physically and chemically so the freeze drying process is carried out to obtain solid form micelle with better characteristics. During freeze drying, protectants are needed to prevent micelles aggregation and irreversible fusion. The aim of this literature review is to study the effect of adding protectants for freeze drying formulation on the micelle’s characteristics. Literature review was made by compiling and comparing the characteristics of freeze dried micelles from 10 different research articles obtained from ScienceDirect and PubMED using predetermined keywords. The result showed that the freeze dried micelles have following characteristics: low CMC, spherical morphology, size <200 nm, small PDI (uniform size), drug loading before and after freeze drying were 2,27-19,52% and 2,03-19,84%, encapsulation efficiency before and after freeze drying were 90,3-99,91% and 79,1-99.91%, and negative zeta potential. In conclusion, adding protectants for the freeze drying process did not affect the CMC. Protectants also can prevent destabilization, aggregation, and irreversible fusion of micelles so that the drug loading, encapsulation efficiency, size, PDI, and size distribution can be maintained. Freeze dried micelles have morphology with the lowest formation energy and negative zeta potential means that micelles are stable and uneasily aggregate. Trehalose and polyethylene glycol are superior beyond other protectants.
| Item Type: | Thesis (Skripsi) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Additional Information: | KKC KK FF F 04/21 Mah p | |||||||||
| Uncontrolled Keywords: | Micelle, Freeze Drying, Protectant | |||||||||
| Subjects: | R Medicine > RM Therapeutics. Pharmacology > RM300-666 Drugs and their actions | |||||||||
| Divisions: | 05. Fakultas Farmasi > Farmastika | |||||||||
| Creators: |
|
|||||||||
| Contributors: |
|
|||||||||
| Depositing User: | sukartini sukartini | |||||||||
| Date Deposited: | 19 Feb 2021 10:00 | |||||||||
| Last Modified: | 19 Feb 2021 10:00 | |||||||||
| URI: | http://repository.unair.ac.id/id/eprint/104181 | |||||||||
| Sosial Share: | ||||||||||
Actions (login required)
 |
View Item |