Prediksi Kelarutan Dan Laju Disolusi Pada Pembentukan Kokristal Apms (Asam P-Metoksisinamat)-Sakarin Dengan Metode Penguapan Pelarut Penelitian Laboratorium – Literature Review

Muhamad Zaesal Rizki Muzaffar (2020) Prediksi Kelarutan Dan Laju Disolusi Pada Pembentukan Kokristal Apms (Asam P-Metoksisinamat)-Sakarin Dengan Metode Penguapan Pelarut Penelitian Laboratorium – Literature Review. Skripsi thesis, UNIVERSITAS AIRLANGGA.

[img] Text (HALAMAN DEPAN)
1. HALAMAN JUDUL.pdf

Download (515kB)
[img] Text (ABSTRAK)
2. ABSTRACT .pdf

Download (136kB)
[img] Text (DAFTAR ISI)
3. DAFTAR ISI .pdf

Download (279kB)
[img] Text (BAB 1 PENDAHULUAN)
4. BAB I PENDAHULUAN .pdf

Download (168kB)
[img] Text (BAB 2 TINJAUAN PUSTAKA)
5. BAB II TINJAUAN PUSTAKA.pdf
Restricted to Registered users only until 26 February 2024.

Download (524kB) | Request a copy
[img] Text (BAB 3 KERANGKA KONSEPTUAL)
6. BAB III KERANGKA KONSEPTUAL.pdf
Restricted to Registered users only until 26 February 2024.

Download (173kB) | Request a copy
[img] Text (BAB 4 METODE PENELITIAN)
7. BAB IV METODE PENELITIAN.pdf
Restricted to Registered users only until 26 February 2024.

Download (402kB) | Request a copy
[img] Text (BAB 5 HASIL PENELITIAN DAN PEMBAHASAN)
8. BAB V HASIL PENELITIAN DAN PEMBAHASAN.pdf
Restricted to Registered users only until 26 February 2024.

Download (1MB) | Request a copy
[img] Text (BAB 6 KESIMPULAN DAN SARAN)
9. BAB VI KESIMPULAN DAN SARAN.pdf
Restricted to Registered users only until 26 February 2024.

Download (33kB) | Request a copy
[img] Text (DAFTAR PUSTAKA)
10. DAFTAR PUSTAKA .pdf

Download (256kB)
[img] Text (LAMPIRAN)
11. LAMPIRAN .pdf
Restricted to Registered users only until 26 February 2024.

Download (2MB) | Request a copy
[img] Text (PERNYATAAN KESEDIAAN PUBLIKASI)
Surat Kesediaan Publikasi - muhamad zaesal.pdf
Restricted to Registered users only

Download (360kB) | Request a copy
Official URL: http://lib.unair.ac.id

Abstract

P-Methoxycinnamic acid (pMCA) is the active compound hydrolyzed from ethyl p-methoxy cinnamic which has an analgesic effect. It has low solubility in water (0,712 mg/mL or 1:1400 water at 25ºC) which can affect to solubility, dissolution rate and bioavailability of pMCA. Therefore, one of the methods to increase the solubility of pMCA was forming cocrystal. The cocrystallization of pMCA with saccharin in molar ratio 1:1 using solvent evaporation method. The purpose of this research is to predict the effect of cocrystal pMCA-saccharin by solvent evaporation method on solubility and dissolution rate. Solubility and dissolution rate predicted by physicochemical characteristics of cocrystal pMCA-saccharin such as melting point from (Differential Thermal Analysis) DTA, the intensity of peak from Powder X-Ray Diffraction (DSXS), and particle size from Scanning Electron Microscope (SEM). The thermogram of cocrystal showed a decrease in the melting temperature compared with pure pMCA. Thermogram from DTA showed an endothermic peak at 163,0ºC. Diffractogram from DSXS showed a decrease in the peak intensity compares with pure pMCA. The peak intensity of the cocrystal 1: 1 is 20,000 counts, lower than the peak intensity of pure pMCA. Microphotograph of cocrystal 1:1 showed different morphologies and lower particle size compared with pure pMCA. Based on a decrease in the melting point, peak intensity, and particle size of cocrystal pMCA-saccharin, cocrystal pMCA-saccharin predicted to increase the solubility and dissolution rate of pMCA.

Item Type: Thesis (Skripsi)
Additional Information: KKC KK FF.F.24-21 Muz p
Uncontrolled Keywords: p-Methoxycinnamic Acid (pMCA), Saccharin, Cocrystal, Physicochemical Characterization, Solubility, Dissolution Rate.
Subjects: R Medicine > RC Internal medicine
R Medicine > RC Internal medicine > RC554-569.5 Personality disorders. Behavior problems Including sexual problems, drug abuse,suicide, child abuse
R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi > Farmastika
Creators:
CreatorsNIM
Muhamad Zaesal Rizki MuzaffarNIM051611133090
Contributors:
ContributionNameNIDN / NIDK
Thesis advisorDwi SetyawanNIDN0030117104
Thesis advisorAbhimata ParamanandanaNIDN0017098902
Depositing User: shiefti dyah alyusi
Date Deposited: 26 Feb 2021 07:03
Last Modified: 26 Feb 2021 07:03
URI: http://repository.unair.ac.id/id/eprint/104443
Sosial Share:

Actions (login required)

View Item View Item