Regina Purnama Dewi Iskandar, - and Alida, - and Ari Triwardhani, - and Ida Bagus Narmada, - and Faizah Hanum, - and Arief Haryo Kusumo, - and Chairul Anwar Nidom, - and Sri Agus Sudjarwo, - (2020) Soluble Human Leukocyte Antigen Molecules Detected in Orofacial Cleft Patients: A Case-Control Study. Pesquisa Brasileira em Odontopediatria e Clínica Integrada, Feb. pp. 1-7. ISSN 1519-0501

	Text (ARTIKEL) Soluble Human Leukocyte Antigen Molecules Detected in Orofacial.pdf Download (214kB)
	Text (SIMILARITY) 8. Soluble Human Leukocyte Antigen Molecules Detected in Orofacial Cleft Patients- A Case-Control Study.pdf Download (2MB)
	Text (PEER REVIEW) Dr.Ari 8..pdf Download (972kB)
	Text (VALIDASI3) 8. Soluble Human Leucocyte.pdf Download (992kB)
	Text (KARIL) 8.Kualitas Karil dan Kesesuaian Bidang Ilmu-Ari8.pdf Download (810kB)

Abstract

Objective: To compare soluble HLA-C and HLA-DR molecules present in the plasma of orofacial cleft and non-orofacial cleft populations. Material and Methods: Orofacial cleft patients were recruited using an Accidental sampling approach (n=15). Peripheral blood was collected from the participants and processed for Enzyme Linked Immunosorbent Assay (ELISA) against HLA-C and HLA-DR with specific antibodies. The absorbance was calculated utilizing ELISA reader. Data were statistically analyzed using an independent t-test to compare the disease and control groups. Results: The levels of soluble HLA-C and HLA-DR were significantly higher in the diseased group compared to the control group (p<0.05). Conclusion: The role of HLA molecules in non-communicable disease and congenital anomalies, particularly orofacial cleft, remains speculative despite the positive results of this study and those of previous investigations. It suggests that the variables examined may affect specific pathways involved in the pathogenesis of orofacial cleft, and predispose the individuals concerned to the oral cleft.

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