Luh Putu Ariyani Pratiwi (2020) Perbandingan Karakteristik Dan Disolusi Kompleks Inklusi Senyawa Obat-Siklodekstrin Yang Dibuat Dengan Metode Solvent Evaporation Dan Co-Grinding. Skripsi thesis, UNIVERSITAS AIRLANGGA.

	Text (HALAMAN DEPAN) 1. HALAMAN DEPAN.pdf Download (981kB)
	Text (ABSTRAK) 2. ABSTRACT.pdf Download (891kB)
	Text (DAFTAR ISI) 3. DAFTAR ISI.pdf Download (1MB)
	Text (BAB 1 PENDAHULUAN) 4. BAB I PENDAHULUAN.pdf Download (1MB)
	Text (BAB 2 TINJAUAN PUSTAKA) 5. BAB II TINJAUAN PUSTAKA.pdf Restricted to Registered users only until 2 March 2024. Download (1MB) | Request a copy
	Text (BAB 3 KERANGKA KONSEPTUAL) 6. BAB III KERANGKA KONSEPTUAL.pdf Restricted to Registered users only until 2 March 2024. Download (1MB) | Request a copy
	Text (BAB 4 METODE PENELITIAN) 7. BAB IV METODE PENELITIAN.pdf Restricted to Registered users only until 2 March 2024. Download (987kB) | Request a copy
	Text (BAB 5 HASIL PENELITIAN DAN PEMBAHASAN) 8. BAB V HASIL DAN PEMBAHASAN.pdf Restricted to Registered users only until 2 March 2024. Download (1MB) | Request a copy
	Text (BAB 6 KESIMPULAN DAN SARAN) 9. BAB VI KESIMPULAN DAN SARAN.pdf Restricted to Registered users only until 2 March 2024. Download (764kB) | Request a copy
	Text (DAFTAR PUSTAKA) 10. DAFTAR PUSTAKA.pdf Download (1MB)
	Text (LAMPIRAN) 11. LAMPIRAN.pdf Restricted to Registered users only until 2 March 2024. Download (2MB) | Request a copy
	Text (PERMOHONAN EMBARGO) EMBARGO - ariyani pratiwi.pdf Restricted to Registered users only Download (157kB) | Request a copy

Abstract

This research is a literature review that discusses a technique to increase the solubility of drug compounds through the formation of inclusion complex with cyclodextrin as a complexing agent. The type of cyclodextrin that is often used in drug development is βCD and HPβCD. According to the published article, the guest molecules are Cabergoline (CAB), Etoposide (EPS), Luteolin (LUT), Bisacodyl (BSD), Olmesartan (OLM), Telmisartan (TLM), and Tosufloxacin Tosylate (TFLX). This review aims to compare physicochemical characteristic and dissolution of the inclusion complex of drugcyclodextrin compounds with solvent evaporation and co-grinding methods. Based on the analysis results, the inclusion complex with the evaporation and co-grinding methods showed changes in physicochemical characteristics and dissolution rates better than the drug compounds. However, the evaporation method gives a higher increase in the dissolved percentage. The evaporation method is more prospective when applied to a large scale because the inclusion complex particles formed are thermodynamically stable, while the co-grinding inclusion complex tends to agglomerate.The mixing and solution stirring of the complex components at a specific temperature, duration, and speed with the solvent evaporation method aids the inclusion of guest molecules into the host molecular cavity during the co-grinding process possesses mechanochemical activation.

Actions (login required)

View Item