M. Abdul Aziz (2020) Pengaruh Pemberian Ekstrak Bawang Hitam (Allium sativum L.) Terhadap Histopatologi Hepar Mencit (Mus musculus) Yang Diberi Paparan Suhu Panas. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

This study aims to determine the effect of black garlic extract (Allium sativum L.) on the liver of mice (Mus musculus) exposed to heat. There were 25 mice (Mus musculus) used in this study which were divided into five groups, each consisting of five mice. Orally, the black garlic extract was given every day for 54 days after the mice were exposed to hot temperature of 40oC. This group consisted of K- (aquadest control group), K + (heat exposure 40oC), P1 (heat exposure 40oC + black garlic extract 125 mg/kgbw), P2 (heat exposure 40oC + black garlic extract 250 mg/kgbw), and P3 (exposure to heat 40oC + black garlic extract 500 mg/kgbw). After 54 days of treatment, the mice were sacrificed and the mice livers were taken for microscopic examination using hematoxylin-eosin staining. The variables observed were hepatocyte degeneration, hepatocyte necrosis, and inflammation. The data obtained from the results of the hepatic histopathological image score were analyzed by the Kruskal-Wallis test and if there were some significant differences between the treatment groups (p <0.05), it would be followed by the Mann-Whitney test. The results of this study indicated that the liver histopathology of the mice had increased liver damage in the K + group (exposure to heat at 40oC) characterized by an increase in the number of degeneration, necrosis, and inflammation. Giving black garlic extract at doses of 125 mg/kgbw, 250 mg/kgbw, and 500 mg/kgbw of black garlic after exposure to heat at 40oC was able to repair liver damage, marked by a decrease in the number of hepatocyte degeneration, hepatocyte necrosis and a decrease in the level of inflammation. The dose of 250 mg/kgbw is the optimal dose that can repair liver damage better than the doses of 125 mg/kgbw and 500 mg/kgbw.

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