Nadya Rinda Eka Rana and Awalia and Yetti Hernaningsih and Hanik Badriyah Hidayati (2019) Manifestasi Neuropsikiatrik Pada Lupus Eritematosus Sistemik Di Rsud Dr. Soetomo Surabaya. Neurona, 36 (4). pp. 293-298. ISSN 0216-6402

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Abstract

Introduction: Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease with unknown causes and extensive clinical manifestations and diverse disease pathways. The clinical manifestations of SLE are very diverse, including the involvement of the nervous system and psychiatric syndrome (neuropsychiatric). Aims: To describe clinical neuropsychiatric manifestations of patients with SLE in Soetomo General Hospital Surabaya. Methods: This was a cross-sectional study based on medical record data on all SLE patients treated at Dr. Soetomo Hospital Surabaya, from January-December 2017. Neuropsychiatric manifestations assessment were based on the nomenclature of the American College of Rheumatology (ACR) in 1999. Results: There were 49 patients, mostly women (98%) with mean age 30,8±10,2 years old. Neurological manifestation was the 3rd most common diagnosis (43%) after hematologic disorder (73.5%) arthritis (53.1%). The manifestations of neuropsychiatric manifestation were mainly seizures (40.8%), headache (34.7%), cerebrovascular disease (26.5%), acute confusional state (20.4%), cognitive dysfunction (6.1%), and polyneuropathy (8.2%). Discussion: The most common neuropsychiatric clinical features in SLE patients are seizures, headache, cerebrovascular disease, and acute confusional state.

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