Muhammad Luthfi, - and Priyawan Rachmadi, - and Aqsa Sjuhada Oki, - and Retno Indrawati, - and Agung Sosiawan, - and Muhaimin Rifai, - (2020) Analysis of lymphocyte T(CD4) cells expression on severe earlychildhood caries and free caries. Infectious Disease Reports 2020, 12 (1). pp. 113-116. ISSN 20367449, 20367430

	Text (ARTICLE) Analysis of lymphocyte T(CD4+).pdf Download (395kB)
	Text (SIMILARITY) Analysis of lymphocyte T(CD4+) cells expression on severe early childhood caries and free caries.pdf Download (1MB)
	Text (TURNITIN) 14. Analysis of lymphocyte T(CD4+) cells expression on severe early childhood caries and free caries.pdf Download (1MB)
	Text (PEER REVIEW) Analysis of lymphocyte T(CD4+).pdf Download (2MB)
	Text (VALIDASI) 2.Dr.Luthfi ( Analysis of Lymphosit...).pdf Download (795kB)
	Text (VALIDASI 2) 12. Analysis of lymphocyte T(CD4+).pdf Download (2MB)
	Text (PENILAIAN) 14. PENILAIAN KARIL DAN BIDANG ILMU.pdf Download (368kB)
	Text (PENELITIAN) 2. Kualitas Karil dan Kesesuaian Bidang Ilmu.pdf Download (501kB)
	Text (KORESPONDEN) 1. Analysis of lymphocyte T(CD4 +) cells expression on severe early childhood caries and free caries.pdf Download (1MB)
	Text (PENILAIAN KARIL) 2. Kualitas Karil dan Kesesuaian Bidang Ilmu.pdf Download (501kB)
	Text (SURAT KEPUTUSAN 1) SK.Rektor Airlangga Comunity.pdf Download (1MB)
	Text (KARIL) 275 KR PENELITIAN DRPM RISTEK BRIN 2021.pdf Download (25MB)
	Text (BUKTI KORESPONDEN) Analysis.pdf Download (2MB)

Abstract

Early childhood caries (ECC) is still one of the many diseases found in children throughout the world. Cariogenic bacteria are a significant risk factor for ECC associated with early colonization and high levels of cariogenic microbes (Streptococcus mutans, S. mutans). Lymphocyte T (CD4) cells known as helper T cells, are effector cells for mediated host immunity. Naive T cells (CD4) must be activated to initiate effector function. This activation occurs through interaction with Professional antigen-presenting cells (pro-APC), especially dendritic cells that lead to intracellular pathways that regulate T cell receptor (TCR) more specifically against antigen in T cells. Lymphocyte cells from samples were collected from severe early childhood caries (S-ECC) and Free caries aged 5 to 6 years. The subjects were instructed to gargle 10 mL of sterile NaCl 1.5% solution for 30 seconds, and expectorate it into a sterile glass then analyzing T lymphocyte cell (CD4+)expression using flow cytometry. Lymphocyte T (CD4) cell expression at SECC (6.2525±64482) while in free caries (8.4138±1.10397) with P-value (P=0. 000). Conclusion of lymphocyte T (CD4+) cells expression at S-ECC is lower than that occurring in free caries

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