PENGARUH JENIS CHITOSAN TERHADAP KARAKTERISTIK FISIK DAN PROFIL PELEPASAN MIKROPARTIKEL KETOPROFEN-CHITOSAN (dibuat dengan metode orifice-ionic gelation)

FITRIA SILVIANA, 050710309 (2012) PENGARUH JENIS CHITOSAN TERHADAP KARAKTERISTIK FISIK DAN PROFIL PELEPASAN MIKROPARTIKEL KETOPROFEN-CHITOSAN (dibuat dengan metode orifice-ionic gelation). Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Microparticles of ketoprofen could be developed to avoid gastrointestinal irritation. The aim of research is to investigate effect of chitosan with different viscosity (Low : 19 cps ; Medium : 44 cps) on physical characteristics and in vitro release of ketoprofen-chitosan. Microparticles of ketoprofen were prepared by orifice-ionic gelation method using 21G syringe. The obtained microparticles was evaluated for its morphology and particle size, drug content, and drug release in phosphate buffer media pH 6,8. The result showed that as the chitosan viscosity increased, the mean partcle size of microparticles decreased, with smoother surface and spherical shape, encapsulation efficiency increased.. Drug release in phosphate buffer media pH 6,8 decreased as the chitosan viscosity increased.

Item Type: Thesis (Skripsi)
Additional Information: KKB KK2 FF 384 11 Sil p
Uncontrolled Keywords: CHITOSAN
Subjects: R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi
Creators:
CreatorsEmail
FITRIA SILVIANA, 050710309UNSPECIFIED
Contributors:
ContributionNameEmail
ContributorRetno Sari,, Dra. M.Sc., AptUNSPECIFIED
Depositing User: Turwulandari
Date Deposited: 02 Feb 2012 12:00
Last Modified: 09 Jun 2017 19:57
URI: http://repository.unair.ac.id/id/eprint/10898
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