Meida Ayu Kusuma (2015) Pengaruh Jumlah Obat Terhadap Karakteristik Fisik Nanopartikel Artesunat-Karboksimetil Kitosan (Dibuat Dengan Metode Gelasi Ionik Dalam Larutan Etanol : Air). Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Nanoparticles is defined as particles or a dispersion of solid particles with a size ranging from 10-1000 nm that consist of polymer and drugs in which drugs can be entrapped,encapsulated or mixed with polymer. Nanoparticles has advantages as controlled release system, targeted delivery system and can improve the bioavailability of poorly water soluble drugs. Biocompatible and biodegradable polymers such as carboxymethyl chitosan (CM chitosan) polymer can be used as nanoparticles matrix. This study use artesunat as model BCS class II drug which is difficult to dissolve in water and low bioavailability. Artesunat nanoparticles is expected to increase it’s solubility and bioavailability. The objective of this study was to investigate the effect of artesunate amount on physical characteristic of artesunate-carboxymethyl chitosan nanoparticles. Nanoparticles with different amount of artesunate were prepared by ionic gelation using CM chitosan as polymer and CaCl2 as cross linker in etanol:aqueous solution and dried by spray drying. The result showed that artesunate amount has effect on morphology and recovery of artesunate-carboxymethyl chitosan nanoparticles. Particle size of dried particles was heterogen and morphology of obtained particles were spherical. As the amount of artesunate increased,the drug efficiency increased.

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