Retno Widyowati, - and Melanny Ika Sulistyowati, - and Nguyen Hoang Uyen, - and Sachiko Sugimoto, - and Yoshi Yamano, - and Hideaki Otsuka, - and Katsuyoshi Matsunami, - (2020) New Methyl Threonolactones and Pyroglutamates of Spilanthes acmella (L.) L. and Their Bone Formation Activities. Molecules, 25 (11). pp. 1-11. ISSN 1420-3049

	Text (FULLTEXT) C-07 Artikel.pdf Download (6MB)
	Text (PEER REVIEW) c7.pdf Download (1MB)
	Text (SIMILARITY) C-07 Similarity.pdf Download (3MB)
	Text (FULLTEXT (RW)) C-05_artikel.pdf Download (28MB)
	Text (Kualitas Karil (RW)) Kualitas Karil C-05.pdf Download (488kB)
	Text (Similarity (RW)) C-05_similarity.pdf Download (2MB)

Abstract

In our continuing research for bioactive constituents from natural resources, a new methyl threonolactone glucopyranoside (1), a new methyl threonolactone fructofuranoside (2), 2 new pyroglutamates (3 and 4), and 10 known compounds (5–14) were isolated from the whole plant of Spilanthes acmella (L.) L. The structures of these compounds were determined based on various spectroscopic and chemical analyses. All of the isolated compounds were evaluated on bone formation parameters, such as ALP (alkaline phosphatase) and mineralization stimulatory activities of MC3T3-E1 cell lines. The results showed that the new compound, 1,3-butanediol 3-pyroglutamate (4), 2-deoxy-d-ribono-1,4-lactone (6), methyl pyroglutamate (7), ampelopsisionoside (10), icariside B1 (11), and benzyl α-l-arabinopyranosyl-(1→6)-β-d-glucopyranoside (12) stimulated both ALP and mineralization activities.

Actions (login required)

View Item