KADAR HUMAN BETA DEFENSIN 2 ( HBD-2) PADA KELOMPOK KARIES DAN BEBAS KARIES

KOERNIASARI ERAIKO SUDJARWO, 021011046 (2013) KADAR HUMAN BETA DEFENSIN 2 ( HBD-2) PADA KELOMPOK KARIES DAN BEBAS KARIES. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Defensins are antimicrobial peptide which classified into two subfamilies, the α-, and β- defensins. Human β defensins 1 (HBD-1), β defensins 2 (HBD-2), β defensins 3 (HBD-3), β defensins (HBD4) and α defensins 1-4 (HNP1-4) have an important role in caries. In the oral cavity, HBD-2 are present in saliva and have antimicrobial activities against oral bacteria, including Streptococcus mutans, a primary etiologic agent of dental caries. This study aimed to determine levels of β defensins 2 (HBD-2) in saliva samples of caries and free caries. Saliva samples were obtained from 50 students of elementary school were divided into two group: the caries-free group and caries group. The salivary levels of β defensins 2 (HBD-2) in subjects were measured by enzyme-linked immunosorbent assays (ELISA). The average salivary levels of HBD-2 were 266,15 ng/ml for the caries-free group and 483,63 ng/ml for the caries group respectively. There were significantly difference in the HBD-2 level between patients with caries and patients with free caries (p < 0.05). We conclude that high salivary levels of HBD- 2 may represent a biological response of oral tissue to caries. HBD-2 can be developed as biomarker to indicate caries and a new tool for caries risk assessment.

Item Type: Thesis (Skripsi)
Additional Information: KKA KK KG. 99/14 Sud k
Uncontrolled Keywords: free caries
Subjects: R Medicine > RK Dentistry
Divisions: 02. Fakultas Kedokteran Gigi
Creators:
CreatorsEmail
KOERNIASARI ERAIKO SUDJARWO, 021011046UNSPECIFIED
Contributors:
ContributionNameEmail
ContributorWisnu Setyari J, drg., M.kesUNSPECIFIED
Depositing User: Dwi Marina
Date Deposited: 04 Feb 2014 12:00
Last Modified: 03 Aug 2016 04:10
URI: http://repository.unair.ac.id/id/eprint/19535
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