DAYA ANTIBIOFILM FLAVONOID KULIT MANGGIS TERHADAP BAKTERI Porphyromonas gingivalis

APRILLIA SONYA FEDERIKA, 021111118 (2015) DAYA ANTIBIOFILM FLAVONOID KULIT MANGGIS TERHADAP BAKTERI Porphyromonas gingivalis. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Background. Necrosis teeth need a procedure called the root canal treatment to eliminate microorganisms in root canal, so the inflammation process did not continue to the periapical.One of the microbes that exist in the necrosis teeth is Porphyromonas gingivalis, that capable of forming biofilm because it has the ability to communicate with bacteria signaling (quorum sensing). It is necessary to discover another antibiofilm agent as an irrigation material in root canal preparation deriving from nature. Flavonoid mangosteen pericarp extract can disrupt acylhomoserine lactones (AHLs) so that quorum sensing bacteria will be disrupted and causing permanent attachment and the establishment of colonies on the surface of the teeth any barrier. Purpose. The aim of this study was to find the antibiofilm activity of flavonoid mangosteen pericarp extract against Porphyromonas gingivalis bacteria. Method. This research has a laboratory experimental with post test only group design. Porphyromonas gingivalis ATCC 33277 was diluted according to Mc. Farland standard 106 CFU/ml in Tryptic Soy Broth (TSB) medium and inserted into microtitterplate flexible U bottom. Porphyromonas gingivalis was incubated for 6x24 hour and checked with a simple staining to see the formation of biofilm. Flavonoid mangosteen pericarp extract was added in various concentrations and OD (optical density) readings done with a wavelength of 595 nm. Result. Flavonoid mangosteen pericarp extract showed a decrease of OD value from control in all concentrations. Conclusion. Flavonoid mangosteen pericarp extract has antibiofilm activity against Porphyromonas gingivalis bacteria

Item Type: Thesis (Skripsi)
Additional Information: KKA KK KG. 32/15 Fed e
Uncontrolled Keywords: FLAVONOID; MANGSOTEEN; PORPHYROMONAS GINGIVALIS
Subjects: R Medicine > RK Dentistry > RK1-715 Dentistry
Divisions: 02. Fakultas Kedokteran Gigi
Creators:
CreatorsNIM/NIDN
APRILLIA SONYA FEDERIKA, 021111118UNSPECIFIED
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorUNSPECIFIEDUNSPECIFIED
Depositing User: Ani Sistarina
Date Deposited: 04 Feb 2015 12:00
Last Modified: 06 Jul 2017 21:32
URI: http://repository.unair.ac.id/id/eprint/19818
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