Asri Ayu Pratiwi (2015) Pengaruh Pemberian Ekstrak Bawang Merah (Allium ascalonicum L.) Terhadap Penurunan Kadar Glukosa Darah Tikus Putih (Rattus norvegicus) Yang Diinduksi Aloksan. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

This study was obtained to determine hypoglicemic and antidiabetic effect of repeated oral administration of shallot extract (Allium ascalonicum L) in alloxan induced diabetic rats (Rattus norvegicus). Alloxan were intraperitoneally injected 120 mg/KgBW (single dose). A total of twenty five male wistar rats of three months old were used in study. The rats were devided into five groups. 1) negative control group (K-) treated by CMC Na 0.5 %, 2) positive control group (K+) treated by metformin 45 mg/KgBW as a standard drug, 3) extract of Allium ascalonicum 250 mg/KgBW (P1), 4) extract of Allium ascalonicum 500 mg/KgBW (P2), 5) extract of Allium ascalonicum 750 mg/KgBW (P3). Hypoglicemic of Allium ascalonicum extract of all rats was determined in 14 days post treatment. Blood specimen were collect from lateralis vein, then analyzed using easytouch glucometer. The result of this study showed that Allium ascalonicum extraxt has high antidiabetic potential at decreased blood glucose. Treatment dose of Allium ascalonicum administration is 750 mg/KgBW. Allium ascalonicum could be expected to lower blood glucose levels because the content therein queercetin. Comparatively, the Allium ascalonicum extract was found to be more effective than the metformin as a standard drug.

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