JOKO DWI WIJAYANTO, 060413305 (2012) PENGARUH PEMBERIAN JINTAN HITAM (Nigella sativa) TERHADAP JUMLAH SEL BETA PADA PANKREAS TIKUS PUTIH (Rattus norvegicus) YANG DIINJEKSI ALLOXAN. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

The purpose of this study was to find out the effect of giving black cumin against pancreatic beta cells white rat after injected by alloxan. Twenty-five rats were divided into five groups P0 P1, P2, P3 and P4. P0 as a negative control group of beta cell normal and the P1 as a positive control beta cell damage alloxan mice injected with 120 mg / kg bw, group P2, P3 and P4 were received black cumin with each dose is 5 mg / kg bw , 10 mg / kg bw, and 15 mg / kg bw respectively for seven days and injected with alloxan 120 mg / kg bw to maintain the number of pancreatic beta cells. Pancreas samples taken 96 hours after alloxan injection to count the number of beta cells. Data were collected and analyzed using ANOVA and Tukey method of Multiple Range Tests and processed using the computer program SPSS 17 software. The results showed that there was no significant difference in the number of pancreatic beta cell. The conclusion that can be taken based on the statistical results of the black cumin is unable to maintain the number of pancreatic beta cells because the provision of black cumin (Nigella sativa) had no effect on the number of pancreatic beta cells of white rats (Rattus norvegicus) that were alloxan-induced due to the formed of radical hydroxyl which cause damage to DNA in beta cells by alloxan., then than it is necessary for advanced research.

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