Gambaran Histopatologi Pankreas Dan Kadar Glukosa Darah Mencit Model Diabetes Yang Diterapi Ekstrak Air Cynodon Dactylon Fraksi Non-Polisakarida

Martia Rani Tacharina (2015) Gambaran Histopatologi Pankreas Dan Kadar Glukosa Darah Mencit Model Diabetes Yang Diterapi Ekstrak Air Cynodon Dactylon Fraksi Non-Polisakarida. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Official URL: http://lib.unair.ac.id

Abstract

This study was undertaken to investigate the hypoglicemic and antidiabetic effect of repeated oral administration of the non-polisacharide fraction of aqueous extract of Cynodon dactylon (NPF-CD) in STZ (streptozotocin) induced diabetic mice, STZ multiple low doses were intraperitoneally administered 40 mg/kgBW for five days. A total of twenty five male BALB-C mice of two months old were used in this study. The mice were devided into five groups: (1) negative control group (K0), that were diabetic and treated solven aquades and tween80, (2) positive control group (K1), that were diabetic and treated metformin as a standart drug, (3) NPF-CD 250 mg/kgBW (P1), (4) NPF-CD 500 mg/kgBW (P2), (5) NPF-CD 1000 mg/kgBW (P3). The treatment was conducted for 14 days. Hypoglicemic effect of NPF-CD of all mice was determined at 6 and 14 days post trearment. At the end of experiment, all of mice were eutanized and the pancreas were collect by abdominal section for analysis of quantity cells in Langerhans pancreatic islet. The result of this study showed that non-polysacharide fraction of aquoeus extract of Cynodon dactylon has high antidiabetic potential at decreased blood glucose and increased quantity of cell in Langerhans pancreatic islet. Comparatively, the NPF-CD was found to be more effective than the metformin as a standart drug.

Item Type: Thesis (Skripsi)
Additional Information: KKC KK KH. 41/15 Tac g
Uncontrolled Keywords: Antidiabetic Activity, Hypoglicemic Activity, Beta Cell, Streptozotocin, Non-Polisacharide Fraction Of Cynodon Dactylon
Subjects: Q Science
Divisions: 06. Fakultas Kedokteran Hewan
Creators:
CreatorsNIM
Martia Rani TacharinaNIM061111103
Contributors:
ContributionNameNIDN / NIDK
Thesis advisorKusnotoNIDN0010036303
Thesis advisorRochmah KurnijasantiNIDN0019077004
Depositing User: Ms noviyanti wulandari
Date Deposited: 28 May 2015 12:00
Last Modified: 10 Jun 2020 14:07
URI: http://repository.unair.ac.id/id/eprint/21125
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