GRETANIA RESIDIWATI, 061011052 (2014) THE EFFECT OF Cosmos caudatus LEAF ETHANOL EXTRACT IN LIVER ON PARACETAMOL INDUCED ELEVATION SGOT AND SGPT IN BALB/c MICE. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Pet animals and humans are at risk for developing toxicosis of drugs, include paracetamol that caused hepatic function as a major problem in the health world till now. One of Indonesian plant that is familiar with high content of flavonoid is Cosmos caudatus. The purpose of this study was to know the effect of Cosmos caudatus leaf ethanol extract especially as a hepatoprotector with preventing the elevation level of SGOT / AST enzyme and SGPT / ALT enzyme in the blood of male BALB/c mice that were exposed by paracetamol. 20 male BALB/c mice were divided randomly into four treatment groups as follows; P1: were given 1 ml/kg BW of CMC Na 1% suspension daily, P2: were given 1 ml/kg BW CMC Na 1% suspension daily and 1 g/kg BW of paracetamol on the 14th day, P3: were given 400 mg/kg BW of Cosmos caudatus leaf extract and 1 g/kg BW of paracetamol on the 14th day, P4: were given 800 mg/kg BW of Cosmos caudatus leaf extract and 1 g/kg BW of paracetamol on the 14th day of treatment. From the result, the maximum ability of Cosmos caudatus leaf extract in dose of 400 mg/kg BW and 800 mg/kg BW as hepatoprotector for preventing the elevation of SGOT (serum glutamate oxaloacetat transaminase) / AST enzyme and SGPT (serum glutamate pyruvat transaminase) / ALT enzyme level in blood of male BALB/c mice that were exposed by paracetamol can’t be seen well because of the less of the control and induced group for their ability as a standard parameters.

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