Prastya Idihastuti, 060911302 (2012) KEMAMPUAN PENGHAMBATAN EKSTRAK DAUN SIRSAK (Annona muricata Linn.) TERHADAP VIABILITAS SEL KANKER MAMMAE MENCIT. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

The purpose of this research was to prove that Annona muricata Linn. leaf extract had an inhibition effect to inhibit breast cancer cell growth of mice. This research used animal strain Balb-c mice by 25 mouse were made to suffer breast cancer. Mice were divided into 5 groups with 5 animals for each group. Positif control group (P1), treatment group P2, P3, and P4 which given Annona muricata Linn. leaf extract for 21 days with various doses, 10 mg/kgbw, 30 mg/kgbw, and 100 mg/kgbw, P5 comparative control group (Cyclophosphamide) with dose 6 mg/kgbw. Necroption was done at 8th week, the viability of breast cancer cell in each treatment was counted by calculating the numbers of living cell and the dead by trypan blue staining of 0,4%. Data was analized by analysis of variance multifactor and continued with tukey HSD test. The results showed that Annona muricata Linn. leaf extract at a dose of 30 mg/kgbw could decrease breast cancer cell growth by 26.474% from 65.580% to 39.106% (p<0,05).

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