Dwi Setianing Bekti, 060810035 (2012) PENGARUH PEMBERIAN EKSTRAK DAUN SALAM (Eugenia polyantha) TERHADAP HISTOPATOLOGI GINJAL TIKUS Sprague dawley SETELAH DIINDUKSI 7,12-Dimetilbenz (a) antrasen (DMBA). Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

The purpose of this study was to evaluate the changes of kidney histophatology after 20 mg/kg BW DMBA (7,12 Dimetilbenz[a]antrasen) induced and Eugenia polyantha extract on Sprague dawley rats kidney cell. The reasearch has been done on February 2011-Desember 2011 at Faculty of Veterinary Medicine, Airlangga University. 20 female rats (Rattus norvegicus strain Sprague dawley) aged 45 days with BW 60-70 gr were used. Devided into five groups; rats in the first group was only given with DMBA and corn oil; second group was given with CMC-Na and corn oil. The third group was given with Eugenia polyantha extract dose 250 mg/kg Bw and DMBA. The fourth and fifth group were given the same treatment as the third group, only using higher dose of Eugenia polyantha was 500 and 750 mg/kg BW. The data were compared using Kruskal-Wallis and Mann-Withney test. Statistical comparisons were performed using SPSS 18.0 for windows. This research showed that Eugenia polyantha extract with DMBA induction could repair kidney cell at dose 500 mg/kg BW.

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