PENGARUH ENDOSULFAN TERHADAP PERUBAHAN HISTOPATOLOGI HEPAR MENCIT ( Mus musculus)

Hana Cipka Pramuda Wardhani, 061111193 (2015) PENGARUH ENDOSULFAN TERHADAP PERUBAHAN HISTOPATOLOGI HEPAR MENCIT ( Mus musculus). Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

The most contaminated organ by exposure is liver, because its function as a detoxificator. The aim of this research is to find out histopathological changes of mice liver (Mus musculus) caused by Endosulfan. Experimental animals are 20 male mice with 20 gram bodyweight. Per-oral exposure using single dose of Endosulfan on each treatment. After 7 days adaptation, group treatment on eighth day as much as 1cc per-oral with the following dose: P1 6,25mg/KgBW/1cc/oral, P2 12,5mg/KgBW/1cc/oral and P3 25mg/KgBW/1cc/oral. On the tenth day, necropsy was done to collect the liver of mice and to make the micro slide. This research using Complete Random Design with lottery. Liver cell which have inflammation, degeneration, and necrosis counted by scoring system. Scoring result analyzed by Kruska-Wallis. If the result shows P<0,05 (significantly different) then followed by Mann-Whitney. The result of this research showed that Endosulfan takes effect on histopathological changes of mice liver. The highest dose 25mg/KgBW may cause poisoned and death. The lowest dose 6,25mg/KgBB may cause inflammation, degeneration, and necrosis on histopathological of mice liver. The higher dose to be administered the more severe the pathological changer.

Item Type: Thesis (Skripsi)
Additional Information: KKC KK KH. 78-15 War p
Uncontrolled Keywords: ENDOSULFAN; HISTOPATHOLIGY
Subjects: S Agriculture > SF Animal culture > SF600-1100 Veterinary medicine
Divisions: 06. Fakultas Kedokteran Hewan
Creators:
CreatorsEmail
Hana Cipka Pramuda Wardhani, 061111193UNSPECIFIED
Contributors:
ContributionNameEmail
ContributorThomas V. Widiyatno, Dr., drh., M.Si.UNSPECIFIED
Depositing User: shiefti dyah alyusi
Date Deposited: 24 Jun 2015 12:00
Last Modified: 23 Sep 2016 03:05
URI: http://repository.unair.ac.id/id/eprint/21645
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