BETTY LUKIATI, 090810022 D (2012) POTENSI EKSTRAK TEMUGIRING (Curcuma heyneana Val van Zijp) TERHADAP MEKANISME PERBAIKAN SEL BETA PANKREAS TIKUS HASIL INDUKSI MLD-STZ. Disertasi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Diabetes mellitus (DM) ordinarally cause both anatomic and functionall organ was damage. Herbal therapy using Curcuma heyneana ethanolic extract is one of Diabetes mellitus (DM) treatment. Research were designed to reveal effect of C. heyneana ethanolic extract on blood glucose contain repearing of DM rats. The research devided in two part, (1) descriptive research: substances screnning and antioxidant activity test of C. heyneana ethanolic extract, (2) experimental research: effect of C. heyneana ethanolic extract on IL-1β expression, iNOS distribussion, NO concentration, SOD activity, insulin concentration, and the pancreatic beta cells damage of DM rats. DM type 1 rats induced by 20 mg/kgBW streptozotocin for 5 consecutive days use as animals model. C. heyneana ethanolic extract were given administrated to DM rats in varying doses of 36, 72, and 108 mg/Kg BW for 7 consecutive days. Data were analyzed by Analysis of variance. The result of descriptive research showed that C. heyneana ethanolic extract contain terpenoid, flavonoid, and 0,665% curcumin. C. heyneana has antioxidant activity with IC50=47,95 μg/ml. According to the one way ANOVA showed that C. heyneana ethanolic extract was able to decrease IL-1β, iNOS, NO, and increase SOD activity, insulin product and repaire the pancreatic beta cells damage on DM rats induced by MLD-STZ. The optimal dose of ethanolic extract of C. heyneana for therapy DM rats is 72 mg/kg BW.

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