PENGARUH PEMBERIAN KAFEIN PERORAL TERHADAP JUMLAH SEL NEURON DAN TEBAL LAPISAN GRANULER GIRUS DENTATUS FORMATIO HIPPOCAMPALIS

KUSUMA EKO PURWANTARI, PURWANTARI (2015) PENGARUH PEMBERIAN KAFEIN PERORAL TERHADAP JUMLAH SEL NEURON DAN TEBAL LAPISAN GRANULER GIRUS DENTATUS FORMATIO HIPPOCAMPALIS. Thesis thesis, UNIVERSITAS AIRLANGGA.

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Official URL: http://lib.unair.ac.id

Abstract

Background.The administration of caffeine can influence the adult neurogenesis in SGZ that play a role in learning and memory functions. Mechanism of neurogenesis by administration of caffeine through adenosine A1 receptor antagonis and Phosphodiesterase enzyme. Caffeine is expected to preventive the deterioration of learning and memory function due to age. Purpose.This study examines the effect of caffeine on the number of neuron cells and a thick layer of granular Dentate gyrus. It can evaluate the maturation stage of neurogenesis after migration from SGZ layer. Method. A total of 28 male rats (Rattus norvegicus) Wistar strain were divided into 4 groups of K, X1, X2, X3 are respectively given oral doses of 37.5 mg caffeine / kg / day, 56.2 mg / kg / day, and 75 mg / kg / day, once a day for 7 days. After treatment, the animals were sacrificed . The brain tissue was taken at parallel sections of the temporal lobe of hippocampalis formatio, to be made of histology preparations. Result. Data were obtained, analyzed by one-way ANOVA (p = 0.05). The analysis shows a significant difference in the number of neuronal cells (p = 0.00) and the granular layer thickness (p = 0.00) between groups gyrus dentatus K and groups X1, X2 and X3. Conclusion. The administration of caffeine can increase the number of neuron cells and the thick layer of granular Dentate gyrus formatio hippocampalis.

Item Type: Thesis (Thesis)
Additional Information: KKA KK TKD. 02/15 Pur p
Uncontrolled Keywords: Caffeine, neuron cells of granular layer, the thick of granular layers
Subjects: R Medicine > RA Public aspects of medicine > RA1-1270 Public aspects of medicine > RA421-790.95 Public health. Hygiene. Preventive medicine
R Medicine > RA Public aspects of medicine > RA1-1270 Public aspects of medicine > RA421-790.95 Public health. Hygiene. Preventive medicine > RA440-440.87 Study and teaching. Research
Divisions: 01. Fakultas Kedokteran
Creators:
CreatorsEmail
KUSUMA EKO PURWANTARI, PURWANTARIUNSPECIFIED
Contributors:
ContributionNameEmail
ContributorAri Gunawan,, Prof. H. , dr., MS., PhD., PA (K).UNSPECIFIED
Depositing User: Nn Aimmatul Mukaromah
Date Deposited: 2016
Last Modified: 30 Oct 2016 20:07
URI: http://repository.unair.ac.id/id/eprint/33814
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