PENGARUH PEMBERIAN EKSTRAK ETANOL DAUN DEWA (Gynura pseudochina (L) DC) TERHADAP KADAR KOLESTEROL TOTAL, KOLESTEROL HDL, KOLESTEROL LDL DALAM SERUM TIKUS JANTAN HIPERKOLESTEROLEMIK.

Tajuddin Abdullah, 090114591 M (2003) PENGARUH PEMBERIAN EKSTRAK ETANOL DAUN DEWA (Gynura pseudochina (L) DC) TERHADAP KADAR KOLESTEROL TOTAL, KOLESTEROL HDL, KOLESTEROL LDL DALAM SERUM TIKUS JANTAN HIPERKOLESTEROLEMIK. Thesis thesis, UNIVERSITAS AIRLANGGA.

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Official URL: http://lib.unair.ac.id

Abstract

This research was intended to study the effect of an ethanolic extract of Gynura pseudochina (L) DC on serum total-cholesterol, HDL-cholesterol, and LDLcholesterol levels of adult male rats (Rattus norvegicus) Wistar strain made hypercholesterolemic by comsuming high lipid diet. Fivty rats aged 3 months, weighting 150 - 250 were used in this study. Ten rats (group Bo) were sacrificed before the comsumption of the high lipid diet to obtain the basal level of serum total cholesterol. The remaining 40 were given a high lipid diet for 4 weeks At the end of this period, again 10 rats were sacrified (group B 1) at which time the total cholesterol level was significantly higher than the Bo group i.e : 68,7 mg/dl and 78,2 mg/dl resp. The remaining 30 rats were then divided into 3 groups of 10 each, i.e. group Po, PI and PII. The high lipid diet continued for 2 weeks more, in which group Po was not given the ethanolic extract, group PI and group PII, were given ethanolic extracts amounting to 150 mg/bw, and 300 mg/bw resp. At the end of the the treatment all the rats were sacrificed and the serum lipoproteins were analyzed. The data collected were then analized statistically by Multip; e analysis of variance (Manova) in significance level of 5 %. The result showed that the administration of Gynura pseudochina ethanolic extract reduced significantly the serum total cholesterol (Po = 81,5 PI = 73,5 PH = 71,0) and LDL-Cholesterol, (Po = 28,0 PI = 20,7 PII = 20,2) while the HDL-cholesterol. Levels were significantly increased (Po = 46,0 PI = 54,3 PII = 49,8). No significant difference were observed between PI and PII. It was concluded that a dose of 150 mg/bw is sufficient to improve the lipid profile in hypercholesterolemic rats. The active substances which may playa role in this case were thought to be saponin and flavonoid, present in the etanolic ex1ract of Gynura pseudochina.

Item Type: Thesis (Thesis)
Additional Information: KKA KK TKD 22/04 Abd p
Uncontrolled Keywords: Gynura pseudochina (Daun dewa), saponins, flavonoids, hypercholesterolemia, lipid profile, total cholesterol, LDL-cholsterol, HDL-cholesterol
Subjects: K Law > K Law (General) > K1-7720 Law in general. Comparative and uniform law. Jurisprudence > K(520)-5582 Comparative law. International uniform law > K3651-3654 Alcohol. Alcoholic beverages
R Medicine > RB Pathology > RB37-56.5 Clinical pathology. Laboratory technique
R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions: 09. Sekolah Pasca Sarjana
Creators:
CreatorsNIM/NIDN
Tajuddin Abdullah, 090114591 MUNSPECIFIED
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorSri Utari PS, -UNSPECIFIED
ContributorAGUS BUDIMAN L, -UNSPECIFIED
Depositing User: Tn Joko Iskandar
Date Deposited: 2016
Last Modified: 23 Sep 2016 08:34
URI: http://repository.unair.ac.id/id/eprint/35384
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