EFEK ANTIBAKTERI Streptomyces sp-MWS1, Streptomyces sp-MWS3, DAN Streptomyces sp-MWS6 TERHADAP Klebsiella pneumoniae NON-PENGHASIL Extended-Spectrum -Lactamase (ESBL) DAN Klebsiella pneumoniae PENGHASIL Extended-Spectrum -Lactamase (ESBL) PENELITIAN EKSPE

YUANI SETIAWATI, 090810198 (2011) EFEK ANTIBAKTERI Streptomyces sp-MWS1, Streptomyces sp-MWS3, DAN Streptomyces sp-MWS6 TERHADAP Klebsiella pneumoniae NON-PENGHASIL Extended-Spectrum -Lactamase (ESBL) DAN Klebsiella pneumoniae PENGHASIL Extended-Spectrum -Lactamase (ESBL) PENELITIAN EKSPE. Thesis thesis, UNIVERSITAS AIRLANGGA.

[img]
Preview
Text (ABSTRAK)
gdlhub-gdl-s2-2013-setiawatiy-24453-6.abst-t.pdf

Download (134kB) | Preview
[img] Text (FULLTEXT)
46.pdf
Restricted to Registered users only

Download (2MB) | Request a copy
Official URL: http://lib.unair.ac.id

Abstract

Klebsiella pneumoniae is one of the causative agent nosocomial infection. The main concern on this bacterium is directed on the extended-spectrum -lactamase (ESBL)-producing Klebsiella pneumoniae. The therapy of ESBL-producing Klebsiella pneumoniae infections is very limited. In mangrove East Coast of Surabaya, it had been found new local isolates Streptomyces sp-MWS1, Streptomyces sp-MWS3, and Streptomyces sp-MWS6. These isolates have potential to produce antibiotics (Retnowati, 2008). This study was aimed to prove these isolates may inhibit the growth of non ESBL-producing Klebsiella pneumoniae and ESBL-producing Klebsiella pneumoniae, and that are differences between the antibacterial activity of these isolates. The test of antibacterial activity of Streptomyces sp-MWS1, Streptomyces sp-MWS3, and Streptomyces sp-MWS6 using the modification Agar print method against clinical isolates of non ESBL-producing Klebsiella pneumoniae and ESBL-producing Klebsiella pneumoniae. The diameter of inhibition zone (mm) formed shows activity of these isolates. The profiles of antibacterial activity of Streptomyces sp-MWS1, Streptomyces sp-MWS3, and Streptomyces sp-MWS6 were different in terms of periode required to reach peak activity, duration of activity and inhibition zone diameter produced during 10 days of observation. Streptomyces sp-MWS3 reached the peak activity most rapidly on day 3 with the largest inhibition zone diameter of 12 mm in non ESBL-producing Klebsiella pneumoniae and 9 mm in ESBL-producing Klebsiella pneumoniae. These isolates produced larger inhibition zone diameter in the non ESBL-producing Klebsiella pneumoniae. There were significant differences in inhibition zone diameter between Streptomyces sp-MWS1, Streptomyces sp-MWS3, and Streptomyces sp-MWS6 against non ESBL-producing Klebsiella pneumoniae and ESBL-producing Klebsiella pneumoniae.

Item Type: Thesis (Thesis)
Additional Information: KKA KK TKD.10/13 Set e; KKB KK-2 TKD.10/13 Set e; KKC KK TKD.10/13 Set e
Uncontrolled Keywords: Streptomyces sp., Klebsiella pneumoniae, extended-spectrum -lactamase (ESBL)-producing Klebsiella pneumoniae
Subjects: R Medicine > R Medicine (General)
Divisions: 09. Sekolah Pasca Sarjana > Ilmu Kedokteran Dasar
Creators:
CreatorsNIM/NIDN
YUANI SETIAWATI, 090810198UNSPECIFIED
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorAchmad Basori, Dr., Apt., MSUNSPECIFIED
ContributorWiwin Retnowati, Dr., S.Si, M.KesUNSPECIFIED
Depositing User: Nn Husnul Khotimah
Date Deposited: 2016
Last Modified: 11 Oct 2016 03:58
URI: http://repository.unair.ac.id/id/eprint/37046
Sosial Share:

Actions (login required)

View Item View Item