PERBANDINGAN PENGARUH PEMBERIAN ANGKAK DENGAN EKSTRAK DAUN JAMBU BIJI TERHADAP JUMLAH TROMBOSIT DAN MEGAKARIOSIT TIKUS PUTIH TROMBOSITOPENIA PENELITIAN EKSPERIMENTAL LABORATORIS

SUNDARI INDAH WIYASIHATI, 010941012 (2011) PERBANDINGAN PENGARUH PEMBERIAN ANGKAK DENGAN EKSTRAK DAUN JAMBU BIJI TERHADAP JUMLAH TROMBOSIT DAN MEGAKARIOSIT TIKUS PUTIH TROMBOSITOPENIA PENELITIAN EKSPERIMENTAL LABORATORIS. Thesis thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Thrombocytopenia is an important parameter in Dengue Hemorrhagic Fever (DHF). Herbal therapies have been used by the community to increase the platelet count in DHF cases, e.g. red yeast rice and guava leaf extract. The purpose of this study is to compare the effect of red yeast rice with guava leaf extract on the increase of platelet and bone marrow megakaryocyte count in thrombocytopenic rats. Thirty male Wistar rats were divided into 5 groups, rendered thrombocytopenia by administering 1.350 u/kg rat BW/day of heparin by subcutaneous injection for a day. K1 was immediately terminated. K2 was continued with administration of placebo for 3 days, K3 with boiling water of 108 mg/kg rat BW/day red yeast rice, K4 with 108 mg/kg rat BW/day red yeast rice powder, and K5 with 270 mg/kg rat BW/day guava leaf extract. The highest platelet and megakaryocyte count were K3, followed by K4, K5, K2, and K1. MANOVA test showed significant differences (p < 0,05). Based on the LSD test, the boiling water of red yeast rice is the most effective remedy to increase platelet and bone marrow megakaryocyte in thrombocytopenic rats. Red yeast rice powder and guava leaf extract showed increasing trend of platelet count in thrombocytopenic rats although not statistically significant

Item Type: Thesis (Thesis)
Additional Information: KKA KK TKD.21/13 Wiy p; KKB KK-2 TKD.21/13 Wiy p; KKC KK TKD.21/13 Wiy p
Uncontrolled Keywords: red yeast rice, guava leaf extract, platelet, megakaryocyte, thrombocytopenia
Subjects: R Medicine > R Medicine (General)
Divisions: 01. Fakultas Kedokteran
09. Sekolah Pasca Sarjana > Ilmu Kedokteran Dasar
Creators:
CreatorsNIM/NIDN
SUNDARI INDAH WIYASIHATI, 010941012UNSPECIFIED
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorTjitra Wardani, dr., M.SUNSPECIFIED
ContributorHarjanto JM, Prof. Dr., dr., AIFMUNSPECIFIED
Depositing User: Nn Husnul Khotimah
Date Deposited: 2016
Last Modified: 17 Oct 2016 07:50
URI: http://repository.unair.ac.id/id/eprint/37057
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