PENGARUH PEMBERIAN ASAM ASKORBAT DOSIS TINGGI SECARA INTRAVENA TERHADAP GAMBARAN HISTOPATOLOGIS GLOMERULUS, TUBULUS GINJAL DAN PEROKSIDASI LIPID PADA TIKUS PUTIH Suatu Penelitian Eksperimental Murni Laboratorik Pada Tikus Putih (Rattus norvegicus strain)

DARMA SATRIA, 011041016 (2012) PENGARUH PEMBERIAN ASAM ASKORBAT DOSIS TINGGI SECARA INTRAVENA TERHADAP GAMBARAN HISTOPATOLOGIS GLOMERULUS, TUBULUS GINJAL DAN PEROKSIDASI LIPID PADA TIKUS PUTIH Suatu Penelitian Eksperimental Murni Laboratorik Pada Tikus Putih (Rattus norvegicus strain). Thesis thesis, UNIVERSITAS AIRLANGGA.

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Abstract

The use of intravenously ascorbic acid in the community is wide range and for many indications. To date, side effects of high dose of ascorbic acid is not known with certainty. This study aim is to prove whether or not the effects of high dose ascorbic acid given intravenously to the kidney damage and prooxidant effect of ascorbic acid. This research design is post test only control group design, using animal model males Rattus norvegicus Wistar strain. The sample size is 25 rats, which is divided into 5 groups. Control group was given 0.5 ml of 0.9% NaCl injection iv, the first treatment group was given injection of 0.75 g/kg iv ascorbic acid, the second treatment group was given an injection of 1 g/kg iv ascorbic acid, the third treatment group was given 1,25 g/kg iv ascorbic acid, the fourth treatment group was given 1.5 g/kg iv ascorbic acid for 14 days. The result did not reveal any glomerular endothelial cells and renal tubular necrosis. The results of MDA levels analized with ANOVA, and there were significant difference on means between the five group (p <0.05). LSD test was performed, there were significant difference between the control group and all treatment groups, groups I and III, IV, group II with III, IV and group III with group IV (p value <0.05). For group I and group II was not found significant differences (p> 0.05). Pearson's correlation analysis, obtained r = - 0.9. In conclusion, there were no glomerular endothelial cells and renal tubular cell necrosis due to administration of high doses of ascorbic acid. High dose of ascorbic acid had antioxidants effect

Item Type: Thesis (Thesis)
Additional Information: KKA KK TKD.42/13 Sat p; KKB KK-2 TKD.42/13 Sat p; KKC KK TKD.42/13 Sat p
Uncontrolled Keywords: Ascorbic acid, glomerular endothelial cell necrosis, renal tubular necrosis, levels of MDA
Subjects: Q Science > QD Chemistry > QD1-999 Chemistry
Q Science > QH Natural history > QH301 Biology
R Medicine > RB Pathology > RB37-56.5 Clinical pathology. Laboratory technique
S Agriculture > SF Animal culture > SF405.5-407 Laboratory animals
Divisions: 09. Sekolah Pasca Sarjana > Ilmu Kedokteran Dasar
Creators:
CreatorsNIM/NIDN
DARMA SATRIA, 011041016UNSPECIFIED
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorTroef Soemarno, dr., MS., SpPA(K)UNSPECIFIED
ContributorI Ketut Sudiana, Drs., M.SiUNSPECIFIED
Depositing User: Nn Duwi Prebriyuwati
Date Deposited: 2016
Last Modified: 11 Jun 2017 18:54
URI: http://repository.unair.ac.id/id/eprint/37138
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