EFEK BAKTERISIDA EKSTRAK VITIS VINIFERA TERHADAP METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS (MRSA) PADA LUKA KULIT RATTUS NORVEGICUS SEBAGAI HEWAN MODEL

Beatrix Curie Panjaitan, - (2013) EFEK BAKTERISIDA EKSTRAK VITIS VINIFERA TERHADAP METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS (MRSA) PADA LUKA KULIT RATTUS NORVEGICUS SEBAGAI HEWAN MODEL. Other thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Methicillin Resistant Staphylococcus Aureus (MRSA) is one of the most common pathogens worldwide that can cause variety of skin and soft tissue infection and can be fatal causing septicemia. Searching for drug and chemical compounds against MRSA is still in demand. Grape is consumed widely around the world, and the seed (Vitis Vinifera) is considered as a waste product but in study in vitro proven to be a rich source of polyphenolic compounds that show antibacterial effect against MRSA. The aim of this study is to investigate the antibacterial effect of grape seed extract on MRSA on white rat (Rattus Norvegicus) Wistar strain skin wound and compare the antibacterial effect to mupirocin’s effect on MRSA. Methods : Experimental research design using posttest only control group design. The wound at the back site of 27 healthy male white rats Wistar strain (Rattus Norvegicus) inoculated with MRSA. The swab specimens taken 6 hours after inoculation of MRSA, on day 1 and day 3 after the treatment with grape seed extract (Vitis Vinifera) and mupirocin.for microbiological examination to count the number of colonies. Result : On all of the wounds in which were applied topical grape seed extract, the number of colonies of MRSA was significantly raised with respect to the control in 1x24 hours (p<0,005) and decreased (p< 0,0001) after 3x24 hours, while treated with mupirocin significantly decreased within 1x24 hours. Discussion : The research showed that grape seed extract has antibacterial effect, but it has slower effect compared to mupirocin

Item Type: Thesis (Other)
Additional Information: KKA KK PPDS. IBP 02/13 Pan e
Uncontrolled Keywords: MRSA, antibacterial effect, Vitis Vinifera, polyphenolic
Subjects: Q Science > QD Chemistry > QD415-436 Biochemistry
Q Science > QR Microbiology > QR75-99.5 Bacteria
R Medicine > RL Dermatology
S Agriculture > SF Animal culture > SF405.5-407 Laboratory animals
Divisions: 01. Fakultas Kedokteran > Ilmu Bedah Plastik
Creators:
CreatorsEmail
Beatrix Curie Panjaitan, -UNSPECIFIED
Contributors:
ContributionNameEmail
ContributorM. Sjaifuddin Noer, Prof., dr., SpB., SpBP-RE (K)UNSPECIFIED
ContributorLobredia Zarasade, dr., SpBP-RE(KKF)UNSPECIFIED
Depositing User: Nn Duwi Prebriyuwati
Date Deposited: 06 Sep 2016 07:24
Last Modified: 06 Sep 2016 07:24
URI: http://repository.unair.ac.id/id/eprint/37177
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