PENGARUH PEMBERIAN XANTHONE TERHADAP GAMBARAN HISTOPATOLOGI SEL HEPAR TIKUS PUTIH JANTAN (Rattus norvegicus) YANG DIINDUKSI KARBON TETRAKLORIDA (CCl4) Penelitian Eksperimental Laboratorik

MEUTIA MAULINA, NIM011141017 (2013) PENGARUH PEMBERIAN XANTHONE TERHADAP GAMBARAN HISTOPATOLOGI SEL HEPAR TIKUS PUTIH JANTAN (Rattus norvegicus) YANG DIINDUKSI KARBON TETRAKLORIDA (CCl4) Penelitian Eksperimental Laboratorik. Thesis thesis, UNIVERSITAS AIRLANGGA.

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Abstract

The purpose of this research is to study the effects of xanthone toward the figure of liver cells histopathology in male white rats (Rattus norvegicus) induced by carbon tetrachloride (CCl4). This research is laboratory experiment by using the post test only control group design. For this purpose, 25 male white rats of species Rattus norvegicus strain Wistar were used. The male white rats were divided into 5 groups were 2 control groups and 3 treatment groups. The first control group were not given any toxin induced liver injury. The second control group were given CCl4 to induced liver injury. The first until third treatment groups were given xanthone with gradually dose 35, 70 and 140 mg/KgBW/day and also given CCl4 to induced liver injury. Liver samples to evaluate histopathologycal of steatosis and necrosis as indicators of liver injury were collected on day 22. The data were analysed by Anova, then continued with LSD test. The result of this study indicated that administration of xanthone with dose 35and 70 mg/KgBW/day have significant effects toward liver cells injury, that is decrease steatosis and necrosis of liver cells. Administration of xanthone with dose 140 mg/KgBW/day showed different effects toward steatosis and necrosis of liver cells, there are have significant effect to decrease necrosis but have no significant effect to decrease steatosis. The highest protective effect appeared from second treatment group with given dose 70 mg/KgBW/day of xanthone. Conclusion of this study demonstrate that administration of xanthone dose 35, 70 and 140 mg/KgBW/day can decrease necrosis of liver cells in male white rats induced by CCl4. Administration of xanthone with dose 35 and 70 mg/KgBW/day also can decrease steatosis of liver cells, but dose 140 mg/KgBW/day of xanthone have no ability to decrease steatosis of liver cells significantly.

Item Type: Thesis (Thesis)
Additional Information: KKA KK TKD. 60/13 Mau p
Uncontrolled Keywords: xanthone, Rattus norvegicus, liver cells, steatosis, necrosis.
Subjects: Q Science > QD Chemistry > QD1-999 Chemistry
Q Science > QH Natural history > QH301 Biology
S Agriculture > SF Animal culture > SF405.5-407 Laboratory animals
S Agriculture > SF Animal culture > SF600-1100 Veterinary medicine > Including veterinary genetics, ethology, anatomy, physiology, embryology, pathology
Divisions: 09. Sekolah Pasca Sarjana > Ilmu Kedokteran Dasar
Creators:
CreatorsNIM/NIDN
MEUTIA MAULINA, NIM011141017NIM011141017
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorH. Ari Gunawan, Prof., dr., M.S., PA(K), Ph.DUNSPECIFIED
ContributorH. Sudibjo, dr., M.S., PA(K)UNSPECIFIED
Depositing User: Nn Duwi Prebriyuwati
Last Modified: 01 Sep 2016 07:04
URI: http://repository.unair.ac.id/id/eprint/38496
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