EFEK PEMBERIAN EKSTRAK KULIT MANGGIS (garcinia mangostana L) DIBANDINGKAN DENGAN GLIMEPIRIDE TERHADAP KADAR GULA DARAH PADATIKUS PUTIH JANTAN GALUR WISTAR ( Rattus norwegicus L ) YANG DI INDUKSI STREPTOZOTOSIN

Dewi Mutmainnah Mahartini, 011214153001 (2014) EFEK PEMBERIAN EKSTRAK KULIT MANGGIS (garcinia mangostana L) DIBANDINGKAN DENGAN GLIMEPIRIDE TERHADAP KADAR GULA DARAH PADATIKUS PUTIH JANTAN GALUR WISTAR ( Rattus norwegicus L ) YANG DI INDUKSI STREPTOZOTOSIN. Thesis thesis, UNIVERSITAS AIRLANGGA.

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Abstract

The purpose of this study is to prove that the mangosteen peel extract affects blood sugar levels drop on white male Wistar rats induced streptozotosin (STZ). This study used a randomized design of the posttest only control group design. The sample consisted of 4 groups with a sample size of 7 animals each group of mice. All samples were prepared STZ induction of diabetes with a single dose of 50 mg / Kg bw through intraperitonel (IP). K0 (control group; given 1% CMC 1 cc / day), K1 (treatment group 1; given 0,054 mg glimepiride / 200 grBB, K2 (treatment group 2; given mangosteen peel extract 50 mg / Kg BW), K3 (perlakuan3 group; given the mangosteen peel extract 100 mg / Kg BW). Timing of therapy in each group for 7 days. Shapiro-Wilk normality test ( = 0.05) in the BB Δ variable data, pre-post STZ GDP and Δ GDP. Levene's test of homogeneity of the Test. ANOVA test of difference when the data were normally distributed and homogeneous. Brown- Forsythe test when the data were normally distributed and are not homogeneous, then proceed to test T-test 2 free samples. The results: 1) There were significant differences between K0 Δ GDP with K1 (p = 0.015), K0 to K2 (p = 0.003) and group K0 to K3 (p = 0.002), 2) Whereas no difference was shown in the K1 with K2 (p = 0.442), K1 to K3 (p = 0,401) and K2 to K3 (p = 0.878). Conclusion: The administration of mangosteen peel extract doses of 50 and 100 mg / kg bw / day did not differ in lowering blood sugar levels compared with glimepiride administration of a dose of 0.054 mg / 200 grBB rat / day. Mangosteen peel extract dose of 100 mg / kg bw / day and 50 mg / kg bw / day did not provide a significant difference in lowering blood sugar levels.

Item Type: Thesis (Thesis)
Additional Information: KKA KK. TKD. 03-14 Mah e
Uncontrolled Keywords: bark extract of mangosteen pericarp (Garcinia mangostana L.), STZ, diabetes mellitus, blood sugar levels
Subjects: R Medicine
Divisions: 09. Sekolah Pasca Sarjana > Ilmu Kedokteran Dasar
Creators:
CreatorsNIM/NIDN
Dewi Mutmainnah Mahartini, 011214153001UNSPECIFIED
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorChoesnan Effendi, ,dr.,AIFUNSPECIFIED
ContributorHarlina, dr.,MS.UNSPECIFIED
Depositing User: Nn Deby Felnia
Date Deposited: 27 Oct 2016 18:30
Last Modified: 27 Oct 2016 18:30
URI: http://repository.unair.ac.id/id/eprint/39139
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