PERBANDINGAN HASIL SCHIRMER-I PASCA PEMBERIAN TIMOLOL 0.5% DENGAN DAN TANPA PRESERVATIVE BENZALKONIUM CHLORIDE 0,01% (Studi Eksperimental pada Oryctolagus cuniculus)

REZEKIAN, NIM011080113 (2016) PERBANDINGAN HASIL SCHIRMER-I PASCA PEMBERIAN TIMOLOL 0.5% DENGAN DAN TANPA PRESERVATIVE BENZALKONIUM CHLORIDE 0,01% (Studi Eksperimental pada Oryctolagus cuniculus). Thesis thesis, Universitas Airlangga.

[img]
Preview
Text (ABSTRAK)
8. ABSTRAK.pdf

Download (237kB) | Preview
[img] Text (FULLTEXT)
PPDS.IKM.03-16 Rez p.pdf
Restricted to Registered users only

Download (1MB) | Request a copy
Official URL: http://lib.unair.ac.id

Abstract

Objective : To study the comparison of Schirmer-I result after instillation of 0,5% timolol with and without preservative for two weeks on New Zealand white rabbit (Oryctolagus cuniculus). Methods : This an experimental study on twenty healthy New Zealand male rabbits (Oryctolagus cuniculus), weighing between 2.5 to 3.5 kg, to 2 groups. Ten rabbits was given 0.5 % timolol eyedrop with Benzalkonium chlorida (BAC) 0.01% as preservative and ten rabbits was given 0.5% timolol without preservative for two weeks. Schirmer-I result was done on day 0, 3rd, 5th, 7th, and 14th. Result : There was significant decrease of Schirmer-I result in both groups from day 3, day 5, day 7, and day 14 (p = 0.000). However the preservative group showed a significantly larger decrease in Schirmer-I compare to non preservative group. Significant difference was found on Schirmer I on day 3 (p=0.013), day 5 (p=0.002), day 7 (p=0.000) between preservative and non preservative groups. Conclusions : This study shows a difference in Schirmer-I result between the preservative group (0.5% timolol with preservative agent Benzalkonium chlorida (BAC) 0.01%) and non preservative group. Timolol itself can decrease Schirmer-I test result, but the additional preservative showed more significant decrease in Schirmer-I.

Item Type: Thesis (Thesis)
Additional Information: KKA KK PPDS.IKM.03/16 Rez p
Uncontrolled Keywords: New Zealand Rabbit, Schirmer -I tear test, 0.5% Timolol , Benzalkonium Chloride (BAC) 0,01%
Subjects: R Medicine > RE Ophthalmology
Divisions: 01. Fakultas Kedokteran > Ilmu Penyakit Mata
Creators:
CreatorsNIM
REZEKIAN, NIM011080113NIM011080113
Contributors:
ContributionNameNIDN / NIDK
Thesis advisorEddyanto, dr.,Sp.M(K)UNSPECIFIED
Thesis advisorHari Basuki, Dr.,dr.,M.KesUNSPECIFIED
Depositing User: Guruh Haris Raputra
Date Deposited: 28 Jul 2016 03:11
Last Modified: 28 Jul 2016 03:11
URI: http://repository.unair.ac.id/id/eprint/39959
Sosial Share:

Actions (login required)

View Item View Item