MATRIKS DAN SCAFFOLD KOMPOSIT BOVINE HYDROXYAPATITE-GELATIN SEBAGAI SISTEM PENGHANTARAN ALENDRONAT PADA CELAH (DEFECT) TULANG AKIBAT KANKER TULANG ATAU OSTEOPOROSIS

Aniek Setiya Budiatin,, 0012125911 (2013) MATRIKS DAN SCAFFOLD KOMPOSIT BOVINE HYDROXYAPATITE-GELATIN SEBAGAI SISTEM PENGHANTARAN ALENDRONAT PADA CELAH (DEFECT) TULANG AKIBAT KANKER TULANG ATAU OSTEOPOROSIS. UNIVERSITAS AIRLANGGA, SURABAYA. (Unpublished)

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Abstract

Bovine hydroxyapatite and gelatin (BHA-riEL) composite were used as hone Ii a biodegradable drug delivery system (DDS) filr the administration of alendronat I treatment of bone defect was caused by osteoporosis and bone cancer. were ynthesi/ materials, which ovoid activaties of osteocia . are exclusively composed of alcfll; bioactive bovine hydroxyapatite and gelatin were manufacture as pellet 01 thl components and characterized in vitro and in vivo. (ross-linking reaction was rClI control the water penetration, swelling and release of alendronate from the rellet characterization with FTIR ; SEM and alendronate release from the pellet at conditiup· and temperature body were studied tor 4 weeks. The Result that the BHA-GEL-ALE cross-linking with glutaraldehyde (t,, biodegradable,nontoxic to human osteoblasts and promote their proliferation. as hon and it was able to control release ALE which inhibit osteoclas activaties as drug ·it system (nOS) ofalendronate.

Item Type: Other
Additional Information: KKC. KK. LP. 40-14 Bud m
Uncontrolled Keywords: bovine hydroxyapatite; gelatin; alendronate: gluraldehyde: drug delivcn (DDS); bone filler, biodegradable.
Subjects: Q Science
Divisions: 08. Fakultas Sains dan Teknologi
Creators:
CreatorsNIM/NIDN
Aniek Setiya Budiatin,, 0012125911UNSPECIFIED
Depositing User: Mr Bambang Husodo
Date Deposited: 15 Sep 2016 03:29
Last Modified: 15 Sep 2016 03:29
URI: http://repository.unair.ac.id/id/eprint/42548
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