Pengaruh tahapan reaksi terhadap persentase hasil sintesis 1,3-Dibenzoilurea

Rini Susanti, 050112457 (2005) Pengaruh tahapan reaksi terhadap persentase hasil sintesis 1,3-Dibenzoilurea. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

In this research, synthesis 1,3-dibenzoylthiourea was done by using two different ways, which were one step and two steps acylation. The one step acylation was done by reacting thiourea and benzoyl chloride in 1:3 mole equivalency to give 1,3-dibenzoylthiourea directly, while the two steps acylation was conducted by reacting thiourea with benzoyl chloride to give benzoylthiourea which was re-reacted with be nzoyl chloride to generate 1,3-dibenzoylthiourea. Purification of compound was done by preparative layer chromatography to give white and odorless crystals. The identification of the resulted compound was done by TLC test, melting point test, UV-Vis spectrophotometry, FT-IR spectrophotometry and 1 H-NMR spectrometry. Identification showed that the resulted compound was a new compound which was posses –NH group, C=O ester group, and phenyl with para substitution. These methods gave average yield for this compund 12,68 % for the one step acylation and 4,41% for the two steps acylation. Keywords : 1,3-dibenzoylthiourea, acylation, thiourea, benzoylthiourea

Item Type: Thesis (Skripsi)
Additional Information: Koleksi Ruang Baca FF 1958/FF/05 Sus p
Uncontrolled Keywords: 1,3-dibenzoylthiourea, acylation, thiourea, benzoylthiourea
Subjects: R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi > Kimia Farmasi
Creators:
CreatorsNIM/NIDN
Rini Susanti, 050112457UNSPECIFIED
Depositing User: petugas
Date Deposited: 30 Nov 2016 18:28
Last Modified: 30 Nov 2016 18:28
URI: http://repository.unair.ac.id/id/eprint/47021
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