YUYUD TRI WAHYUNI, 059811997
(2003)
STUDI MUTU FISIK DAN KESERAGAMAN KANDUNGAN SEDIAAN KAPSUL (ISONIAZID 200 MG) HASIL RACIKAN BEBERAPA APOTEK DI KECAMATAN GUBENG.
Skripsi thesis, UNIVERSITAS AIRLANGGA.
Abstract
One of the pharmaceutical works conducled in dispensary is 10 serve prescriptions in the form of dispensed capsule preparations. The dispensed capsule preparations (capsule preparation of isoniazid 200 mg) made by the dispensary should be in good quality. So, an investigation in capsule quality is considered important concerning with the quality of Physical capsule and the uniformity of its active ingredients.
In examination of the weight unifonnity of the capsule contains showed that all apotek have not fulfilled the spesification of weight homogeneity of weight uniformity. In the examination of the pounding degree of bulk shows that bulk of all capsule contains have not fulfilled the specification of pounding degree of bulk. The examination of active ingredients in capsules is conducted by using speklrophotometry uv-vis with the method of 3 A, at maximum 'A equals 265,6 urn. The average result of % Isoniazid active ingredients of capsules dispensed by these dispensaries have fulfilled the specification provided by Indonesian Pharmacopoeia Most of the included dispensaries have value % KV ~ 6 % indicating that there is no unifonnity of Isoniazid active ingredients in each capsule indicated.
For this reason, a further investigation to find out the causes of why dispensed capsule preparations have not fulfilled the above specifications is considered necessary. As a result, there will be a recommended correct method to obtain the specified-dispensed capsules.
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