EFFORTS TO PRODUCE l-(BENZOYlOXY)UREA AS ANTICANCER DRUG CANDIDATE

Suko Hardjono (2014) EFFORTS TO PRODUCE l-(BENZOYlOXY)UREA AS ANTICANCER DRUG CANDIDATE. In: The 1st International Conference on Pharmaceutics & Pharmaceutical Sciences Proceedings. Faculty of Pharmacy Universitas Airlangga, Surabaya, pp. 245-247. ISBN 978-602-72333-0-0

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Abstract

Hydroxyurea is an antineoplastic compound which has activity to inhibit ribonucleotide re-ductase enzyme. The function of the enzyme 15 to inhibit DNA biosynthesis by converting ribonucleotides to deoxyribonucleotides. Hydroxyurea IS also useful in treatment of sickle cell anemia because it eases the paint of the patients, which has been attribute to its ability o generate nitric oxide, a potent vasodilator. Nitric oxide may also contribute to the antitumor effect of hydroxyuirea, since it is known to inhibit ribonucleotide reductase probably because it contains an unpalred.electron and therefore It is able to quench the thyrosine radical.

Item Type: Book Section
Uncontrolled Keywords: Drugs; Anticancer
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
R Medicine > RM Therapeutics. Pharmacology > RM300-666 Drugs and their actions
Divisions: 05. Fakultas Farmasi
Creators:
CreatorsEmail
Suko Hardjonosuko.hardjono@yahoo.com
Depositing User: Ika Rudianto
Date Deposited: 20 Jan 2017 00:13
Last Modified: 15 Jun 2017 18:01
URI: http://repository.unair.ac.id/id/eprint/51516
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